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Baseline intraocular pressure: an independent risk factor in severe steroid-induced ocular hypertension after intravitreal dexamethasone implant
DC Field | Value | Language |
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dc.contributor.author | 김찬윤 | - |
dc.contributor.author | 배형원 | - |
dc.contributor.author | 성공제 | - |
dc.contributor.author | 최웅락 | - |
dc.date.accessioned | 2024-07-18T05:12:36Z | - |
dc.date.available | 2024-07-18T05:12:36Z | - |
dc.date.issued | 2024-04 | - |
dc.identifier.issn | 0721-832X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/200034 | - |
dc.description.abstract | Purpose: To evaluate the baseline intraocular pressure (IOP)-related risk of severe steroid-induced ocular hypertension (SIOH). We hypothesized that the incidence and severity of SIOH may differ according to baseline IOP in patients who received intravitreal dexamethasone implants. Methods: A total of 889 eyes treated with intravitreal dexamethasone implants and a baseline IOP of ≤ 23 mmHg were enrolled. Enrolled patients were divided into two groups: the steroid-responders (127 eyes) and the non-steroid-responders (762 eyes). The steroid-responders group was subdivided into post-injection IOP of ≥ 25, > 30, or > 35 mmHg or IOP elevation of ≥ 10 mmHg over the baseline value. The odds ratio of SIOH was calculated using univariable logistic regression analysis, and significant variables were analyzed with a multivariable model. IOP was measured before (baseline IOP) and after dexamethasone implant injection at 1 week and 1, 2, 3, 6, and 12 months. Results: Although baseline IOP was significantly associated with the development of SIOH in logistic regression analysis, the results from the subgroup analysis differed. In the group with IOP elevation of ≥ 10 mmHg over the baseline, SIOH was not significantly associated with baseline IOP, but it was significantly related to higher baseline IOP in the severe SIOH group (IOP > 30 and > 35 mmHg). Conclusions: Higher baseline IOP is a risk factor for severe SIOH. Clinicians should be aware of the risk of SIOH when administering steroids intravitreally to patients with high baseline IOP (IOP > 19 mmHg). | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English, German | - |
dc.publisher | Springer-Verlag | - |
dc.relation.isPartOf | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Dexamethasone | - |
dc.subject.MESH | Glaucoma* / complications | - |
dc.subject.MESH | Glucocorticoids | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intraocular Pressure | - |
dc.subject.MESH | Intravitreal Injections | - |
dc.subject.MESH | Macular Edema* / etiology | - |
dc.subject.MESH | Ocular Hypertension* / chemically induced | - |
dc.subject.MESH | Ocular Hypertension* / diagnosis | - |
dc.subject.MESH | Ocular Hypertension* / drug therapy | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Baseline intraocular pressure: an independent risk factor in severe steroid-induced ocular hypertension after intravitreal dexamethasone implant | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | Won Jeong Cho | - |
dc.contributor.googleauthor | Jun Mo Lee | - |
dc.contributor.googleauthor | Hyoung Won Bae | - |
dc.contributor.googleauthor | Chan Yun Kim | - |
dc.contributor.googleauthor | Gong Je Seong | - |
dc.contributor.googleauthor | Wungrak Choi | - |
dc.identifier.doi | 10.1007/s00417-023-06299-4 | - |
dc.contributor.localId | A01035 | - |
dc.contributor.localId | A01814 | - |
dc.contributor.localId | A01946 | - |
dc.contributor.localId | A04123 | - |
dc.relation.journalcode | J00951 | - |
dc.identifier.eissn | 1435-702X | - |
dc.identifier.pmid | 37930443 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s00417-023-06299-4 | - |
dc.subject.keyword | Baseline intraocular pressure | - |
dc.subject.keyword | Dexamethasone implant | - |
dc.subject.keyword | Intraocular pressure | - |
dc.subject.keyword | Risk factor | - |
dc.subject.keyword | Steroid-induced ocular hypertension | - |
dc.contributor.alternativeName | Kim, Chan Yun | - |
dc.contributor.affiliatedAuthor | 김찬윤 | - |
dc.contributor.affiliatedAuthor | 배형원 | - |
dc.contributor.affiliatedAuthor | 성공제 | - |
dc.contributor.affiliatedAuthor | 최웅락 | - |
dc.citation.volume | 262 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1231 | - |
dc.citation.endPage | 1243 | - |
dc.identifier.bibliographicCitation | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, Vol.262(4) : 1231-1243, 2024-04 | - |
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