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TM4SF19-mediated control of lysosomal activity in macrophages contributes to obesity-induced inflammation and metabolic dysfunction
DC Field | Value | Language |
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dc.contributor.author | 현영민 | - |
dc.date.accessioned | 2024-07-18T05:02:17Z | - |
dc.date.available | 2024-07-18T05:02:17Z | - |
dc.date.issued | 2024-03 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199986 | - |
dc.description.abstract | Adipose tissue (AT) adapts to overnutrition in a complex process, wherein specialized immune cells remove and replace dysfunctional and stressed adipocytes with new fat cells. Among immune cells recruited to AT, lipid-associated macrophages (LAMs) have emerged as key players in obesity and in diseases involving lipid stress and inflammation. Here, we show that LAMs selectively express transmembrane 4 L six family member 19 (TM4SF19), a lysosomal protein that represses acidification through its interaction with Vacuolar-ATPase. Inactivation of TM4SF19 elevates lysosomal acidification and accelerates the clearance of dying/dead adipocytes in vitro and in vivo. TM4SF19 deletion reduces the LAM accumulation and increases the proportion of restorative macrophages in AT of male mice fed a high-fat diet. Importantly, male mice lacking TM4SF19 adapt to high-fat feeding through adipocyte hyperplasia, rather than hypertrophy. This adaptation significantly improves local and systemic insulin sensitivity, and energy expenditure, offering a potential avenue to combat obesity-related metabolic dysfunction. © The Author(s) 2024. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Pub. Group | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adipose Tissue / metabolism | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Diet, High-Fat / adverse effects | - |
dc.subject.MESH | Inflammation / metabolism | - |
dc.subject.MESH | Insulin Resistance* | - |
dc.subject.MESH | Lipids | - |
dc.subject.MESH | Lysosomes / metabolism | - |
dc.subject.MESH | Macrophages / metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Obesity* / complications | - |
dc.subject.MESH | Obesity* / genetics | - |
dc.title | TM4SF19-mediated control of lysosomal activity in macrophages contributes to obesity-induced inflammation and metabolic dysfunction | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anatomy (해부학교실) | - |
dc.contributor.googleauthor | Cheoljun Choi | - |
dc.contributor.googleauthor | Yujin L Jeong | - |
dc.contributor.googleauthor | Koung-Min Park | - |
dc.contributor.googleauthor | Minji Kim | - |
dc.contributor.googleauthor | Sangseob Kim | - |
dc.contributor.googleauthor | Honghyun Jo | - |
dc.contributor.googleauthor | Sumin Lee | - |
dc.contributor.googleauthor | Heeseong Kim | - |
dc.contributor.googleauthor | Garam Choi | - |
dc.contributor.googleauthor | Yoon Ha Choi | - |
dc.contributor.googleauthor | Je Kyung Seong | - |
dc.contributor.googleauthor | Sik Namgoong | - |
dc.contributor.googleauthor | Yeonseok Chung | - |
dc.contributor.googleauthor | Young-Suk Jung | - |
dc.contributor.googleauthor | James G Granneman | - |
dc.contributor.googleauthor | Young-Min Hyun | - |
dc.contributor.googleauthor | Jong Kyoung Kim | - |
dc.contributor.googleauthor | Yun-Hee Lee | - |
dc.identifier.doi | 10.1038/s41467-024-47108-8 | - |
dc.contributor.localId | A04814 | - |
dc.relation.journalcode | J02293 | - |
dc.identifier.eissn | 2041-1723 | - |
dc.identifier.pmid | 38555350 | - |
dc.contributor.alternativeName | Hyun, Young-Min | - |
dc.contributor.affiliatedAuthor | 현영민 | - |
dc.citation.volume | 15 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 2779 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, Vol.15(1) : 2779, 2024-03 | - |
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