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Bimetallic Hyaluronate-Modified Au@Pt Nanoparticles for Noninvasive Photoacoustic Imaging and Photothermal Therapy of Skin Cancer

Authors
 Hye Hyeon Han  ;  Seong-Jong Kim  ;  Jiwoong Kim  ;  Wonchan Park  ;  Chulhong Kim  ;  Hyemin Kim  ;  Sei Kwang Hahn 
Citation
 ACS APPLIED MATERIALS & INTERFACES, Vol.15(9) : 11609-11620, 2023-03 
Journal Title
ACS APPLIED MATERIALS & INTERFACES
ISSN
 1944-8244 
Issue Date
2023-03
MeSH
Gold / pharmacology ; Humans ; Metal Nanoparticles* / therapeutic use ; Nanoparticles* ; Photoacoustic Techniques* / methods ; Phototherapy ; Photothermal Therapy ; Skin Neoplasms* / diagnostic imaging ; Skin Neoplasms* / therapy
Keywords
bimetallic nanoparticles ; hyaluronate ; photoacoustic imaging ; photothermal therapy ; transdermal delivery
Abstract
Although spherical gold (Au) nanoparticles have remarkable photothermal conversion efficiency and photostability, their weak absorption in the near-infrared (NIR) region and poor penetration into deep tissues have limited further applications to NIR light-mediated photoacoustic (PA) imaging and noninvasive photothermal cancer therapy. Here, we developed bimetallic hyaluronate-modified Au-platinum (HA-Au@Pt) nanoparticles for noninvasive cancer theranostics by NIR light-mediated PA imaging and photothermal therapy (PTT). The growth of Pt nanodots on the surface of spherical Au nanoparticles enhanced the absorbance in the NIR region and broadened the absorption bandwidth of HA-Au@Pt nanoparticles by the surface plasmon resonance (SPR) coupling effect. In addition, HA facilitated the transdermal delivery of HA-Au@Pt nanoparticles through the skin barrier and enabled clear tumor-targeted PA imaging. Compared to conventional PTT via injection, HAAu@Pt nanoparticles were noninvasively delivered into deep tumor tissues and completely ablated the targeted tumor tissues by NIR light irradiation. Taken together, we could confirm the feasibility of HA-Au@Pt nanoparticles as a NIR light-mediated biophotonic agent for noninvasive skin cancer theranostics.
Full Text
https://pubs.acs.org/doi/10.1021/acsami.3c01858
DOI
10.1021/acsami.3c01858
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199626
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