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Remnant cholesterol, but not low-density lipoprotein cholesterol, is associated with intra-pancreatic fat deposition

Authors
 Loren Skudder-Hill  ;  Ivana R Sequeira-Bisson  ;  Juyeon Ko  ;  Jaelim Cho  ;  Sally D Poppitt  ;  Maxim S Petrov 
Citation
 DIABETES OBESITY & METABOLISM, Vol.25(11) : 3337-3346, 2023-11 
Journal Title
DIABETES OBESITY & METABOLISM
ISSN
 1462-8902 
Issue Date
2023-11
MeSH
Body Mass Index ; Cholesterol ; Cholesterol, HDL ; Cholesterol, LDL ; Humans ; Insulin Resistance* ; Pancreas* / diagnostic imaging ; Triglycerides
Keywords
cardiovascular diseases ; intra-pancreatic fat ; lipid panel ; magnetic resonance imaging ; pancreas ; triglyceride-rich lipoproteins ; triglycerides
Abstract
Aim: To investigate the associations of components of the lipid panel (and its derivatives) with intra-pancreatic fat deposition (IPFD).Methods: All participants underwent abdominal magnetic resonance imaging on the same 3.0-Tesla scanner and IPFD was quantified. Blood samples were collected in the fasted state for analysis of lipid panel components. A series of linear regression analyses was conducted, adjusting for age, sex, ethnicity, body mass index, fasting plasma glucose, homeostatic model assessment of insulin resistance, and liver fat deposition.Results: A total of 348 participants were included. Remnant cholesterol (P = 0.010) and triglyceride levels (P = 0.008) were positively, and high-density lipoprotein cholesterol level (P = 0.001) was negatively, associated with total IPFD in the most adjusted model. Low-density lipoprotein cholesterol and total cholesterol were not significantly associated with total IPFD. Of the lipid panel components investigated, remnant cholesterol explained the greatest proportion (9.9%) of the variance in total IPFD.Conclusion: Components of the lipid panel have different associations with IPFD. This may open up new opportunities for improving outcomes in people at high risk for cardiovascular diseases (who have normal low-density lipoprotein cholesterol) by reducing IPFD.
Full Text
https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.15233
DOI
10.1111/dom.15233
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Cho, Jae Lim(조재림)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199314
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