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Relationship between menopausal hormone therapy and incidence of fractures in postmenopausal women

Authors
 Heeyon Kim  ;  Min Jin Kang  ;  Jin Kyung Baek  ;  Jae Kyung Lee  ;  Eun A Choi  ;  Bo Hyun Yun  ;  Eui Hyeok Kim  ;  Seok Kyo Seo 
Citation
 CLIMACTERIC, Vol.27(2) : 165-170, 2024-04 
Journal Title
CLIMACTERIC
ISSN
 1369-7137 
Issue Date
2024-04
MeSH
Estrogen Replacement Therapy ; Estrogens / pharmacology ; Female ; Hormone Replacement Therapy ; Humans ; Incidence ; Menopause* ; Postmenopause* ; Progesterone / pharmacology ; Retrospective Studies
Keywords
Menopausal hormone therapy ; bone ; fracture ; hormone replacement therapy ; tibolone
Abstract
Objective: Long-term protective effects of menopausal hormone therapy (MHT) at fractures with different doses and components are controversial. We analyzed the effect of MHT on the incidence of spine and femur fractures according to MHT type, age at commencement, duration and dose of hormones in Korean women. Method: This retrospective study evaluated propensity score-matched patients with MHT from the Korean National Health Insurance Service database. Among women aged ≥50 years with menopause between 2004 and 2007, spine and femur fracture incidence until 2017 was analyzed in 36,446 women who had received MHT for >1 year. Estrogen–progesterone therapy (EPT), estrogen-only therapy (ET) or tibolone therapy was conducted. Results: EPT significantly lowered the incidence of spine and femur fractures with a conventional dose, but not with a low dose. Tibolone significantly decreased the incidence of spine fractures in women aged 50–59 years when used for >5 years, and the incidence of femur fractures in women older than 60 years when used for >3 years. ET significantly lowered the risk of femur fractures when estradiol was used for >5 years. Conclusion: In menopausal women, all MHT including conventional-dose EPT, ET and tibolone tended to lower the incidence of fractures. The effects, however, varied with the type of fracture and type of MHT.
Full Text
https://www.tandfonline.com/doi/full/10.1080/13697137.2023.2273528
DOI
10.1080/13697137.2023.2273528
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heeyon(김희연)
Seo, Seok Kyo(서석교) ORCID logo https://orcid.org/0000-0003-3404-0484
Yun, Bo Hyon(윤보현) ORCID logo https://orcid.org/0000-0001-5703-797X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199245
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