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Association between Daily Dietary Calcium Intake and the Risk of Cardiovascular Disease (CVD) in Postmenopausal Korean Women

Authors
 Jae Kyung Lee  ;  Thi Minh Chau Tran  ;  Euna Choi  ;  Jinkyung Baek  ;  Hae-Rim Kim  ;  Heeyon Kim  ;  Bo Hyon Yun  ;  Seok Kyo Seo 
Citation
 NUTRIENTS, Vol.16(7) : 1043, 2024-04 
Journal Title
NUTRIENTS
Issue Date
2024-04
MeSH
Calcium ; Calcium, Dietary ; Cardiovascular Diseases* / epidemiology ; Cardiovascular Diseases* / etiology ; Cross-Sectional Studies ; Female ; Humans ; Myocardial Infarction* / epidemiology ; Myocardial Infarction* / etiology ; Nutrition Surveys ; Postmenopause ; Republic of Korea / epidemiology ; Stroke*
Keywords
Korea national health and nutrition examination survey (KNHANES) ; cardiovascular diseases ; cross-sectional study ; dietary calcium intake ; menopause ; postmenopausal women
Abstract
We aimed to evaluate the association between daily dietary calcium intake and the risk of cardiovascular disease (CVD) in postmenopausal women using data from the Korean National Health and Nutrition Examination Survey (KNHANES). This cross-sectional study included 12,348 women aged 45–70 years who had reached natural menopause. They were classified into three groups according to daily dietary calcium intake: <400 mg, 400–800 mg, and >800 mg. The risks of CVD, stroke, angina, and myocardial infarction were assessed in each group. Further, we performed subgroup analysis according to the post-menopause duration (≤10 vs. >10 postmenopausal years). We performed logistic regression analysis with adjustment for age, menopausal age, income, urban area, education, insulin use, body mass index, hypertension, diabetes mellitus, dyslipidemia, high alcohol intake, smoking, exercise, oral contraceptive use, and hormonal therapy use. Calcium intake level was not significantly associated with the risk of CVD in the total population and the ≤10 postmenopausal years subgroup. However, in the >10 postmenopausal years subgroup, daily calcium intake >800 mg was associated with significantly decreased risks of all CVD (odds ratio [OR], 0.27; 95% confidence interval [CI], 0.11–0.64), stroke (OR, 0.06; 95% CI, 0.01–0.42), and myocardial infarction (OR, 0.27; 95% CI, 0.11–0.64). Our findings suggest that a dietary calcium intake of >800 mg/day decreases the risk of CVD events in women who have been menopausal for 10 years.
Files in This Item:
T202402420.pdf Download
DOI
10.3390/nu16071043
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heeyon(김희연)
Seo, Seok Kyo(서석교) ORCID logo https://orcid.org/0000-0003-3404-0484
Yun, Bo Hyon(윤보현) ORCID logo https://orcid.org/0000-0001-5703-797X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199136
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