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Evaluation of peripheral nerve injury according to the severity of damage using 18F-FDG PET/MRI in a rat Model of sciatic nerve injury

Authors
 Jong Yeol Park  ;  Mi Jee Lee  ;  Hyung Jun Kim  ;  Jung Woo Nam 
Citation
 NEUROLOGICAL RESEARCH, Vol.46(4) : 356-366, 2024-04 
Journal Title
NEUROLOGICAL RESEARCH
ISSN
 0161-6412 
Issue Date
2024-04
MeSH
Animals ; Fluorodeoxyglucose F18 ; Magnetic Resonance Imaging / methods ; Peripheral Nerve Injuries* / diagnostic imaging ; Positron-Emission Tomography / methods ; Radiopharmaceuticals ; Rats ; Sciatic Nerve / diagnostic imaging ; Sciatic Neuropathy* / diagnostic imaging
Keywords
18F-fluorodeoxyglucose (18F-FDG) ; Peripheral nerve injury ; crushing injury ; magnetic resonance imaging (MRI) ; positron emission tomography (PET)
Abstract
Objectives We ascertained that the PET scan may be a valuable imaging modality for the noninvasive, objective diagnosis of neuropathic pain caused by peripheral nerve injury through the previous study. This study aimed to assess peripheral nerve damage according to severity using(18)F-FDG PET/MRI of the rat sciatic nerve. Methods Eighteen rats were divided into three groups: 30-second (G1), 2-minute (G2), and 5-minute (G3) crushing injuries. The severity of nerve damage was measured in the third week after the crushing injury using three methods: the paw withdrawal threshold test (RevWT), standardized uptake values on PET (SUVR), and intensity analysis on immunohistochemistry (IntR). Results There were significant differences between G1 and G3 in both SUVR and IntR (p = 0.012 and 0.029, respectively), and no significant differences in RevWT among the three groups (p = 0.438). There was a significant difference in SUVR (p = 0.012), but no significant difference in IntR between G1 and G2 (p = 0.202). There was no significant difference between G2 and G3 in SUVR and IntR (p = 0.810 and 0.544, respectively). Discussion Although PET did not show results consistent with those of immunohistochemistry in all respects, this study demonstrated that PET uptake tended to increase with severe nerve damage. If this research is supplemented by further experiments, PET/MRI can be used as an effective diagnostic modality.
Full Text
https://www.tandfonline.com/doi/full/10.1080/01616412.2024.2321774
DOI
10.1080/01616412.2024.2321774
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyung Jun(김형준) ORCID logo https://orcid.org/0000-0001-8247-4004
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199102
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