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Glomerulonephritis following COVID-19 infection or vaccination: a multicenter study in South Korea

Authors
 Hyung Woo Kim  ;  Eun Hwa Kim  ;  Yun Ho Roh  ;  Young Su Joo  ;  Minseob Eom  ;  Han Seong Kim  ;  Mi Seon Kang  ;  HoeIn Jeong  ;  Beom Jin Lim  ;  Seung Hyeok Han  ;  Minsun Jung 
Citation
 KIDNEY RESEARCH AND CLINICAL PRACTICE, Vol.43(2) : 165-176, 2024-03 
Journal Title
KIDNEY RESEARCH AND CLINICAL PRACTICE
ISSN
 2211-9132 
Issue Date
2024-03
Keywords
COVID-19 ; COVID-19 vaccines ; Glomerulonephritis ; Kidney diseases ; Multicenter study
Abstract
Background: Despite the widespread impact of the severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019, COVID-19) and vaccination in South Korea, our understanding of kidney diseases following these events remains limited. We aimed to address this gap by investigating the characteristics of glomerular diseases following the COVID-19 infection and vaccination in South Korea.



Methods: Data from multiple centers were used to identify de novo glomerulonephritis (GN) cases with suspected onset following COVID-19 infection or vaccination. Retrospective surveys were used to determine the COVID-19-related histories of patients who were initially not implicated. Bayesian structural time series and autoregressive integrated moving average models were used to determine causality.



Results: Glomerular diseases occurred shortly after the infection or vaccination. The most prevalent postinfection GN was podocytopathy (42.9%), comprising primary focal segmental glomerulosclerosis and minimal change disease, whereas postvaccination GN mainly included immunoglobulin A nephropathy (IgAN; 57.9%) and Henoch-Schönlein purpura nephritis (HSP; 15.8%). No patient progressed to end-stage kidney disease. Among the patients who were initially not implicated, nine patients with IgAN/HSP were recently vaccinated against COVID-19. The proportion of glomerular diseases changed during the pandemic in South Korea, with an increase in acute interstitial nephritis and a decrease in pauci-immune crescentic GN.



Conclusion: This study showed the characteristics of GNs following COVID-19 infection or vaccination in South Korea. Understanding these associations is crucial for developing effective patient management and vaccination strategies. Further investigation is required to fully comprehend COVID-19's impact on GN.
Files in This Item:
T202402313.pdf Download
DOI
10.23876/j.krcp.23.219
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyung Woo(김형우) ORCID logo https://orcid.org/0000-0002-6305-452X
Lim, Beom Jin(임범진) ORCID logo https://orcid.org/0000-0003-2856-0133
Jung, Minsun(정민선) ORCID logo https://orcid.org/0000-0002-8701-4282
Joo, Young Su(주영수) ORCID logo https://orcid.org/0000-0002-7890-0928
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199090
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