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Templated Assembly of Silk Fibroin for a Bio-Feedstock-Derived Heart Valve Leaflet

Authors
 Woojin Choi  ;  Moonhyun Choi  ;  Taesuk Jun  ;  Yongwoo Kim  ;  Du Yeol Ryu  ;  Nam Kyun Kim  ;  Hye-Jin Lee  ;  Yoojin Lee  ;  Seung Hyun Lee  ;  Wonhwa Lee  ;  Milae Lee  ;  Keonwook Kang  ;  Jae-Sung Kwon  ;  Jong Geol Jang  ;  Hojin Ha  ;  Jae Young Choi  ;  Sungmin Lim  ;  Sangmin Lee  ;  Se Yong Jung  ;  Jinkee Hong 
Citation
 ADVANCED FUNCTIONAL MATERIALS, Vol.34(14) : 2307106, 2024-04 
Journal Title
ADVANCED FUNCTIONAL MATERIALS
ISSN
 1616-301X 
Issue Date
2024-04
Abstract
Bioprosthetic valves are employed to replace defective heart valves. However, structural degeneration is prevalent in bioprosthetic valves because the heart valve leaflets are exposed to extreme and repetitive cardiovascular pressure. Herein, a silk fibroin‐based heart valve leaflet, which executes the physiological role of a heart valve, is developed. To this end, a templated assembly technology is developed. Notably, a physically optimal hierarchical structure for replacing the natural heart valve leaflet is realized by numerous firmly stacked β‐sheet crystals distributed within collective tyrosine‐reinforcing amorphous strands. Almost half (46.9%) of the silk fibroin‐based heart valve leaflet comprises strongly stacked β‐sheet crystals, leading to a 292% enhancement in stacking strength. The templated assembly results in the entanglement of amorphous strands, upregulating the non‐covalent interactions within the tyrosine. Consequently, the strength is enhanced by 1380% compared to native silk fibroin. Moreover, the templated assembly enhances the static and dynamic mechanical properties, thereby delivering a desirable performance for its use in heart valve replacement. Interestingly, the aortic valve composed of silk fibroin‐based leaflets does not fail under the cardiovascular pressure of 60–180 mmHg. Furthermore, the valve performance is satisfactory and surmounts the requirements of the industrial standard ISO 5840.
Full Text
https://onlinelibrary.wiley.com/doi/10.1002/adfm.202307106
DOI
10.1002/adfm.202307106
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Jung, Se Yong(정세용) ORCID logo https://orcid.org/0000-0003-1337-563X
Choi, Jae Young(최재영) ORCID logo https://orcid.org/0000-0002-1247-6669
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/199082
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