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Efficacy and safety of a home-use handheld multi-energy-based device for skin rejuvenation: clinical, ex vivo, and histological studies

Authors
 Sooyeon Choi  ;  Jemin Kim  ;  Young In Lee  ;  Sang Gyu Lee  ;  Inhee Jung  ;  Jangmi Suk  ;  Ju Hee Lee 
Citation
 LASERS IN MEDICAL SCIENCE, Vol.39(1) : 38, 2024-01 
Journal Title
LASERS IN MEDICAL SCIENCE
ISSN
 0268-8921 
Issue Date
2024-01
MeSH
Biopsy ; Epidermis ; Female ; Humans ; Prospective Studies ; Rejuvenation* ; Skin*
Keywords
Iontophoresis ; Low-level light ; Microcurrent ; Radiofrequency ; Skin rejuvenation ; Ultrasonic wave
Abstract
Alongside increases in the average lifespan and a growing interest in anti-aging remedies, the demand for at-home skincare devices is rapidly expanding in the cosmetic market. This study aimed to assess the safety and efficacy of a novel home-use handheld multi-energy-based device for skin rejuvenation that simultaneously emits low level light, low-dose radiofrequency, low-energy microcurrent, and low-intensity ultrasonic wave. This prospective, randomized, split-face clinical trial enrolled 36 healthy Korean women. After 8 weeks of device use, parameters associated with skin aging were assessed. Additionally, a preliminary ex vivo study and skin biopsy following device use were performed to confirm safety and efficiency of the device. Parameters associated with skin aging including skin hydration, elasticity, roughness, skin pore size, and eye wrinkle volume showed significant improvements after 8 weeks of the device use, relative to baseline measurements and the control side. No adverse effects were observed during the follow-up period. Results of ex vivo and in vivo skin tissue studies correlated with clinical findings, which showed an increase in the expression of type 1 collagen and a decrease in the expression of matrix metalloproteinase-1, which is related to the skin aging phenotype. The expression of loricrin and involucrin, major components of the epidermal skin barrier, also increased after the use of the device. Multi-energy-based device is effective for skin rejuvenation and tolerable, without any considerable adverse effects. © 2024, The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.
Full Text
https://link.springer.com/article/10.1007/s10103-024-03982-8
DOI
10.1007/s10103-024-03982-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jemin(김제민) ORCID logo https://orcid.org/0000-0001-6628-3507
Lee, Young In(이영인) ORCID logo https://orcid.org/0000-0001-6831-7379
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
Choi, Sooyeon(최수연)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198845
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