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The efficacy of intradermal hyaluronic acid filler as a skin quality booster: A prospective, single-center, single-arm pilot study

Authors
 Joo Hee Lee  ;  Jemin Kim  ;  Yun Na Lee  ;  Sooyeon Choi  ;  Young In Lee  ;  Jangmi Suk  ;  Ju Hee Lee 
Citation
 JOURNAL OF COSMETIC DERMATOLOGY, Vol.23(2) : 409-416, 2024-02 
Journal Title
JOURNAL OF COSMETIC DERMATOLOGY
ISSN
 1473-2130 
Issue Date
2024-02
MeSH
Adult ; Cosmetic Techniques* / adverse effects ; Dermal Fillers* / adverse effects ; Humans ; Hyaluronic Acid / adverse effects ; Middle Aged ; Patient Satisfaction ; Pilot Projects ; Prospective Studies ; Rejuvenation ; Skin Aging* ; Treatment Outcome
Keywords
filler ; hyaluronic acid ; skin aging
Abstract
Background: The use of “skin boosters” comprised of hyaluronic acid (HA)-based fillers to improve skin quality has gained popularity recently, especially in individuals interested in skin rejuvenation. Aim: This study aimed to evaluate the efficacy and safety of intradermal micropuncture injections of HA-based gel filler combined with lidocaine (BYRYZN® SKINBOOSTER HA, ACROSS Co., Ltd., Gangwon-do,

Korea).



Patients/Methods: A prospective, single-arm, open-label pilot study was conducted with study subjects who were aged between 30 and 60 years old and exhibited evidence of skin aging, such as wrinkles and loss of elasticity. They received three injections at 2-week intervals and were followed up for a total of 12 weeks.



Results: Twenty subjects with a mean age of 54.1 years were included. The mean Lemperle wrinkle scale demonstrated a 40% decrease from 2.60 ± 0.60 at baseline to 1.55 ± 0.51 at week 8. The improvement rate was maintained at about 33% until week 12. The average maximum height of the wrinkle (Rz, μm), average skin roughness (Ra, μm), skin elasticity (R2, AU), facial curved length (mm), skin pore size (mm2), skin hydration (AU), TEWL (g/hm2), and skin glossiness (gloss value, AU) exhibited statistically significant improvements over time compared with the baseline measurements. No serious adverse effects or persistent adverse effects were reported, except for a transient subcutaneous nodule in one subject.



Conclusions: This study demonstrates that multiple microinjections of HA-based gel filler for facial skin aging are safe and effective in improving facial skin quality.
Files in This Item:
T202306682.pdf Download
DOI
10.1111/jocd.15944
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jemin(김제민) ORCID logo https://orcid.org/0000-0001-6628-3507
Lee, Young In(이영인) ORCID logo https://orcid.org/0000-0001-6831-7379
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
Choi, Sooyeon(최수연)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198782
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