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Clinical Impact and Risk Factors of Seizure After Liver Transplantation: A Nested Case-Control Study

Authors
 Minyu Kang  ;  Hwa-Hee Koh  ;  Deok-Gie Kim  ;  Seung Hyuk Yim  ;  Mun Chae Choi  ;  Eun-Ki Min  ;  Jae Geun Lee  ;  Myoung Soo Kim  ;  Dong Jin Joo 
Citation
 TRANSPLANT INTERNATIONAL, Vol.37 : 12342, 2024-02 
Journal Title
TRANSPLANT INTERNATIONAL
ISSN
 0934-0874 
Issue Date
2024-02
Keywords
seizure, liver transplantation, hyponatremia, sodium, neurologic complication
Abstract
Seizures are a frequent neurological consequence following liver transplantation (LT), however, research on their clinical impact and risk factors is lacking. Using a nested case-control design, patients diagnosed with seizures (seizure group) within 1-year post-transplantation were matched to controls who had not experienced seizures until the corresponding time points at a 1:5 ratio to perform survival and risk factor analyses. Seizures developed in 61 of 1,243 patients (4.9%) at median of 11 days after LT. Five-year graft survival was significantly lower in the seizure group than in the controls (50.6% vs. 78.2%, respectively, p < 0.001) and seizure was a significant risk factor for graft loss after adjusting for variables (HR 2.04, 95% CI 1.24-3.33). In multivariable logistic regression, body mass index <23 kg/m(2), donor age >= 45 years, intraoperative continuous renal replacement therapy and delta sodium level >= 4 mmol/L emerged as independent risk factors for post-LT seizure. Delta sodium level >= 4 mmol/L was associated with seizures, regardless of the severity of preoperative hyponatremia. Identifying and controlling those risk factors are required to prevent post-LT seizures which could result in worse graft outcome.
Files in This Item:
T202401573.pdf Download
DOI
10.3389/ti.2024.12342
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Minyu(강민유)
Koh, Hwa-Hee(고화희)
Kim, Deok Gie(김덕기)
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Min, Eun-Ki(민은기)
Lee, Jae Geun(이재근) ORCID logo https://orcid.org/0000-0002-6722-0257
Yim, Seung Hyuk(임승혁) ORCID logo https://orcid.org/0000-0003-2146-3592
Joo, Dong Jin(주동진) ORCID logo https://orcid.org/0000-0001-8405-1531
Choi, Mun Chae(최문채)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198728
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