0 88

Cited 0 times in

Donor fat‐to‐muscle ratio and kidney transplant outcomes: A proposition of metabolic memory

Authors
 Youn Kyung Kee  ;  Juhan Lee  ;  Bo Young Nam  ;  Young Su Joo  ;  Shin-Wook Kang  ;  Kyu Ha Huh  ;  Jung Tak Park 
Citation
 DIABETES-METABOLISM RESEARCH AND REVIEWS, Vol.40(2) : e3781, 2024-02 
Journal Title
DIABETES-METABOLISM RESEARCH AND REVIEWS
ISSN
 1520-7552 
Issue Date
2024-02
MeSH
Adult ; Female ; Graft Survival / physiology ; Humans ; Kidney Transplantation* / adverse effects ; Living Donors ; Male ; Middle Aged ; Muscles ; Retrospective Studies
Keywords
DNA methylation ; body composition ; fat ; kidney transplantation ; metabolic memory ; muscle
Abstract
Aims

The impact of donor abdominal fat-to-muscle ratio (FMR) on kidney transplant (KT) outcomes was assessed. Given the transient nature of the donor's metabolic environment in transplant recipients, this study investigated the capacity of body composition to induce metabolic memory effects.



Materials and Methods

KT patients (n = 895) who received allografts from living donors (2003–2013) were included. Donor fat and muscle were quantified using pre-KT abdominal computed tomography scans. Patients were categorised into donor FMR tertiles and followed up for graft outcomes. Additionally, genome-wide DNA methylation analysis was performed on 28 kidney graft samples from KT patients in the low- and high-FMR groups.



Results

Mean recipient age was 42.9 ± 11.4 years and 60.9% were males. Donor FMR averaged 1.67 ± 0.79. Over a median of 120.9 ± 42.5 months, graft failure (n = 127) and death-censored graft failure (n = 109) were more frequent in the higher FMR tertiles. Adjusted hazard ratios for the highest versus lowest FMR tertile were 1.71 (95% CI, 1.06–2.75) for overall graft failure and 1.90 (95% CI, 1.13–3.20) for death-censored graft failure. Genome-wide DNA methylation analysis identified 58 differentially methylated regions (p < 0.05,
Δβ
> 0.2) and 35 genes showed differential methylation between the high- (FMR >1.91) and low-FMR (FMR <1.27) groups.



Conclusions

Donors with increased fat and reduced muscle composition may negatively impact kidney allograft survival in recipients, possibly through the transmission of epigenetic changes, implying a body-composition-related metabolic memory effect.
Full Text
https://onlinelibrary.wiley.com/doi/10.1002/dmrr.3781
DOI
10.1002/dmrr.3781
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Nam, Bo Young(남보영)
Park, Jung Tak(박정탁) ORCID logo https://orcid.org/0000-0002-2325-8982
Lee, Ju Han(이주한)
Joo, Young Su(주영수) ORCID logo https://orcid.org/0000-0002-7890-0928
Huh, Kyu Ha(허규하) ORCID logo https://orcid.org/0000-0003-1364-6989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198718
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links