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Creatinine-cystatin C ratio and death with a functioning graft in kidney transplant recipients

Authors
 Mun Chae Choi  ;  Deok Gie Kim  ;  Seung Hyuk Yim  ;  Hyun Jeong Kim  ;  Hyoung Woo Kim  ;  Jaeseok Yang  ;  Beom Seok Kim  ;  Kyu Ha Huh  ;  Myoung Soo Kim  ;  Juhan Lee 
Citation
 SCIENTIFIC REPORTS, Vol.14(1) : 1966, 2024-01 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2024-01
MeSH
Creatinine ; Cystatin C* ; Female ; Humans ; Kidney Transplantation* ; Male ; Sex Ratio ; Transplant Recipients
Abstract
Death with a functioning graft is important cause of graft loss after kidney transplantation. However, little is known about factors predicting death with a functioning graft among kidney transplant recipients. In this study, we evaluated the association between post-transplant creatinine-cystatin C ratio and death with a functioning graft in 1592 kidney transplant recipients. We divided the patients into tertiles based on sex-specific creatinine-cystatin C ratio. Among the 1592 recipients, 39.5% were female, and 86.1% underwent living-donor kidney transplantation. The cut-off value for the lowest creatinine-cystatin C ratio tertile was 0.86 in males and 0.73 in females. The lowest tertile had a significantly lower 5-year patient survival rate and was independently associated with death with a functioning graft (adjusted hazard ratio 2.574, 95% confidence interval 1.339–4.950, P < 0.001). Infection was the most common cause of death in the lowest tertile group, accounting for 62% of deaths. A low creatinine-cystatin C ratio was significantly associated with an increased risk of death with a functioning graft after kidney transplantation. © 2024, The Author(s).
Files in This Item:
T202401549.pdf Download
DOI
10.1038/s41598-024-52649-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Deok Gie(김덕기)
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
Kim, Hyun Jeong(김현정)
Kim, Hyung Woo(김형우) ORCID logo https://orcid.org/0000-0002-6305-452X
Yang, Jaeseok(양재석)
Lee, Ju Han(이주한)
Yim, Seung Hyuk(임승혁) ORCID logo https://orcid.org/0000-0003-2146-3592
Choi, Mun Chae(최문채)
Huh, Kyu Ha(허규하) ORCID logo https://orcid.org/0000-0003-1364-6989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198712
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