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Distinct changes in brain metabolism in patients with dementia and hearing loss

Authors
 Ji Hyuk Han  ;  Sangwon Lee  ;  Seong Hoon Bae  ;  Mijin Yun  ;  Byung Seok Ye  ;  Jinsei Jung 
Citation
 BRAIN AND BEHAVIOR, Vol.14(1) : e3374, 2024-01 
Journal Title
BRAIN AND BEHAVIOR
Issue Date
2024-01
MeSH
Alzheimer Disease* / pathology ; Brain / pathology ; Cognitive Dysfunction* / pathology ; Dizocilpine Maleate / analogs & derivatives* ; Fluorodeoxyglucose F18 / metabolism ; Hearing Loss* / complications ; Hearing Loss* / metabolism ; Hearing Loss* / pathology ; Humans ; Positron-Emission Tomography
Keywords
FDG-PET ; brain metabolism ; cognitive impairment ; dementia ; hearing loss
Abstract
IntroductionPrevious studies have reported that hearing loss (HL) is associated with dementia, although the mechanistic underpinnings remain elusive. This study aimed to evaluate the changes in brain metabolism in patients with HL and different types of dementia.MethodsPatients with cognitive impairment (CI) and HL treated at the university-based memory clinic from May 2016 to October 2021 were included. In total, 108 patients with CI and HL prospectively underwent audiometry, neuropsychological test, magnetic resonance imaging, and 18F-fluorodeoxyglucose positron emission tomography. Twenty-seven individuals without cognitive impairment and hearing loss were enrolled as a control group. Multivariable regression was performed to evaluate brain regions correlated with each pathology type after adjusting for confounding factors.ResultsMultivariable regression analyses revealed that Alzheimer's disease-related CI (ADCI) was associated with hypometabolic changes in the right superior temporal gyrus (STG), right middle temporal gyrus (MTG), and bilateral medial temporal lobe. Lewy body disease-related CI (LBDCI) and vascular CI were associated with hypermetabolic and hypometabolic changes in the ascending auditory pathway, respectively. In the pure ADCI group, the degree of HL was positively associated with abnormal increase of brain metabolism in the right MTG, whereas it was negatively associated with decreased brain metabolism in the right STG in the pure LBDCI group.ConclusionEach dementia type is associated with distinct changes in brain metabolism in patients with HL.
Files in This Item:
T202401032.pdf Download
DOI
10.1002/brb3.3374
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Bae, Seong Hoon(배성훈) ORCID logo https://orcid.org/0000-0001-9243-9392
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Yun, Mijin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Lee, Sangwon(이상원)
Jung, Jinsei(정진세) ORCID logo https://orcid.org/0000-0003-1906-6969
Han, Ji Hyuk(한지혁)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198631
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