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Risk Factors for Unfavorable Outcomes of Tuberculosis in Korea: Implications for Patient-Centered Care in Tuberculosis Treatment

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dc.contributor.author강영애-
dc.contributor.author김송이-
dc.contributor.author김영삼-
dc.contributor.author김은영-
dc.contributor.author박무석-
dc.contributor.author박영목-
dc.contributor.author신성재-
dc.contributor.author용승현-
dc.contributor.author이상훈-
dc.contributor.author이수환-
dc.contributor.author임아영-
dc.contributor.author정경수-
dc.contributor.author정지예-
dc.contributor.author홍혜영-
dc.contributor.author우아라-
dc.date.accessioned2024-03-22T06:32:05Z-
dc.date.available2024-03-22T06:32:05Z-
dc.date.issued2024-01-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/198570-
dc.description.abstractBackground: The treatment success rate for tuberculosis (TB) has stagnated at 80–81% in South Korea, indicating unsatisfactory outcomes. Enhancing treatment success rate necessitates the development of individualized treatment approaches for each patient. This study aimed to identify the risk factors associated with unfavorable treatment outcomes to facilitate tailored TB care. Methods: We retrospectively analyzed the data of patients with active TB between January 2019 and December 2020 at a single tertiary referral center. We classified unfavorable treatment outcomes according to the 2021 World Health Organization guidelines as follows: “lost to follow-up” (LTFU), “not evaluated” (NE), “death,” and “treatment failure” (TF). Moreover, we analyzed risk factors for each unfavorable outcome using Cox proportional hazard regression analysis. Results: A total of 659 patients (median age 62 years; male 54.3%) were included in the study. The total unfavorable outcomes were 28.1%: 4.6% LTFU, 9.6% NE, 9.1% deaths, and 4.9% TF. Multivariate analysis showed that a culture-confirmed diagnosis of TB was associated with a lower risk of LTFU (adjusted hazard ratio [aHR], 0.25; 95% confidence interval [CI], 0.10–0.63), whereas the occurrence of adverse drug reactions (ADRs) significantly increased the risk of LTFU (aHR, 6.63; 95% CI, 2.63–16.69). Patients living far from the hospital (aHR, 4.47; 95% CI, 2.50–7.97) and those with chronic kidney disease (aHR, 3.21; 95% CI, 1.33–7.75) were at higher risk of being transferred out to other health institutions (NE). Higher mortality was associated with older age (aHR, 1.06; 95% CI, 1.04–1.09) and comorbidities. The ADRs that occurred during TB treatment were a risk factor for TF (aHR, 6.88; 95% CI, 2.24–21.13). Conclusion: Unfavorable outcomes of patients with TB were substantial at a tertiary referral center, and the risk factors for each unfavorable outcome varied. To improve treatment outcomes, close monitoring and the provision of tailored care for patients with TB are necessary.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisher대한의학회(The Korean Academy of Medical Sciences)-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAntitubercular Agents* / adverse effects-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPatient-Centered Care-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHTuberculosis* / drug therapy-
dc.subject.MESHTuberculosis* / epidemiology-
dc.titleRisk Factors for Unfavorable Outcomes of Tuberculosis in Korea: Implications for Patient-Centered Care in Tuberculosis Treatment-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHye Young Hong-
dc.contributor.googleauthorYoungmok Park-
dc.contributor.googleauthorSeung Hyun Yong-
dc.contributor.googleauthorAla Woo-
dc.contributor.googleauthorAh Young Leem-
dc.contributor.googleauthorSu Hwan Lee-
dc.contributor.googleauthorKyung Soo Chung-
dc.contributor.googleauthorSang Hoon Lee-
dc.contributor.googleauthorSong Yee Kim-
dc.contributor.googleauthorEun Young Kim-
dc.contributor.googleauthorJi Ye Jung-
dc.contributor.googleauthorMoo Suk Park-
dc.contributor.googleauthorYoung Sam Kim-
dc.contributor.googleauthorSung Jae Shin-
dc.contributor.googleauthorYoung Ae Kang-
dc.identifier.doi10.3346/jkms.2024.39.e4-
dc.contributor.localIdA00057-
dc.contributor.localIdA00626-
dc.contributor.localIdA00707-
dc.contributor.localIdA00811-
dc.contributor.localIdA01457-
dc.contributor.localIdA05828-
dc.contributor.localIdA02114-
dc.contributor.localIdA06000-
dc.contributor.localIdA02836-
dc.contributor.localIdA02904-
dc.contributor.localIdA03382-
dc.contributor.localIdA03570-
dc.contributor.localIdA03735-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid38225780-
dc.subject.keywordLost to Follow-Up-
dc.subject.keywordPatient-Centered Care-
dc.subject.keywordRisk Factors-
dc.subject.keywordTuberculosis-
dc.contributor.alternativeNameKang, Young Ae-
dc.contributor.affiliatedAuthor강영애-
dc.contributor.affiliatedAuthor김송이-
dc.contributor.affiliatedAuthor김영삼-
dc.contributor.affiliatedAuthor김은영-
dc.contributor.affiliatedAuthor박무석-
dc.contributor.affiliatedAuthor박영목-
dc.contributor.affiliatedAuthor신성재-
dc.contributor.affiliatedAuthor용승현-
dc.contributor.affiliatedAuthor이상훈-
dc.contributor.affiliatedAuthor이수환-
dc.contributor.affiliatedAuthor임아영-
dc.contributor.affiliatedAuthor정경수-
dc.contributor.affiliatedAuthor정지예-
dc.citation.volume39-
dc.citation.number2-
dc.citation.startPagee4-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.39(2) : e4, 2024-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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