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The effects of long-pulsed alexandrite laser therapy on facial redness and skin microbiota compositions in rosacea: A prospective, multicentre, single-arm clinical trial

Authors
 Sujin Park  ;  Hyunwoo Jang  ;  Seol Hwa Seong  ;  Ji Young Kim  ;  Eun Jung Lee  ;  Yu Jeong Bae  ;  Yong Ju Ahn  ;  Jihee Kim  ;  Sang Ho Oh 
Citation
 PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, Vol.40(1) : e12921, 2024-01 
Journal Title
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
ISSN
 0905-4383 
Issue Date
2024-01
MeSH
Adult ; Erythema ; Humans ; Lasers, Solid-State* / therapeutic use ; Middle Aged ; Prospective Studies ; RNA, Ribosomal, 16S ; Rosacea* / radiotherapy ; Treatment Outcome
Keywords
laser ; rosacea ; skin microbiome
Abstract
Background
Rosacea is a chronic skin disorder characterised by abnormal neurovasculature and inflammation in the central region of the face. The efficacy of pulsed-dye laser and intense pulsed light treatments for rosacea have been demonstrated in several clinical trials. However, there is currently no research on the efficacy of long-pulsed alexandrite laser (LPAL) therapy alone for rosacea-related facial redness and its effect on skin microbiota.

Aim
To evaluate the efficacy of LPAL therapy on facial redness in rosacea and assess changes in skin microbiota composition.

Methods
Subjects with rosacea (n = 21, mean age: 39.2 ± 11.3 years) were recruited from two medical institutions and received monthly LPAL treatments (Clarity II™, Lutronic Corp.) for 3 months. At each visit, clinical photographs were taken, and erythema was measured using a spectrometer. At the initial and final visits, the Dermatology Life Quality Index (DLQI) and Skin Sensitivity Questionnaire (SSQ) were evaluated. Skin swabs were obtained at the initial and final visit, and facial microbiome composition was analysed using 16S rRNA amplicon sequencing.

Results
After three LPAL treatment sessions, the average facial erythema index, measured using Mexameter® decreased significantly from 360.0 ± 96.7 at baseline to 312.0 ± 94.5 at the final visit (p < .05). The DLQI and SSQ showed significant improvement of symptoms. Skin microbiome diversity and relative abundance were altered significantly, particularly in the genera Clostridium, Lawsonella, Bacteroides, and Lactobacillus.

Conclusions
LPAL therapy alone showed favourable efficacy for the treatment of facial redness in rosacea, with some impacts on the skin microbiota composition.
Full Text
https://onlinelibrary.wiley.com/doi/10.1111/phpp.12921
DOI
10.1111/phpp.12921
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jihee(김지희) ORCID logo https://orcid.org/0000-0002-0047-5941
Park, Sujin(박수진)
Seong, Seol Hwa(성설화)
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
Lee, Eun Jung(이은정) ORCID logo https://orcid.org/0000-0002-8401-2652
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198499
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