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Low-molecular-weight collagen peptides supplement promotes a healthy skin: A randomized, double-blinded, placebo-controlled study

Authors
 Seol Hwa Seong  ;  Young In Lee  ;  Joohee Lee  ;  Sooyeon Choi  ;  In Ah Kim  ;  Jangmi Suk  ;  Inhee Jung  ;  Chaemin Baeg  ;  Jinhak Kim  ;  Dongchan Oh  ;  Ju Hee Lee 
Citation
 JOURNAL OF COSMETIC DERMATOLOGY, Vol.23(2) : 554-562, 2024-02 
Journal Title
JOURNAL OF COSMETIC DERMATOLOGY
ISSN
 1473-2130 
Issue Date
2024-02
MeSH
Administration, Oral ; Adult ; Collagen / adverse effects ; Dietary Supplements / adverse effects ; Double-Blind Method ; Elasticity ; Humans ; Peptides / adverse effects ; Skin Aging* ; Skin*
Keywords
clinical study ; collagen peptide ; photoaging ; wrinkles
Abstract
Background: Oral collagen peptides supplementation was reported to improve skin integrity and counteract skin aging.

Aims: A randomized, double-blinded, placebo-controlled study was conducted to clinically evaluate the impact of low-molecular-weight collagen peptides on the human skin.

Patients/methods: Healthy adult participants (n = 100) were randomly assigned to receive a test product containing low-molecular-weight collagen peptides or a placebo. Parameters of skin wrinkles, elasticity, hydration, and whitening (melanin and erythema indexes) were measured at baseline and after 4, 8, and 12 weeks.

Results: Compared with the placebo group, the average skin roughness, maximum of all peak-to-valley values, maximum peak height of the wrinkle, and average maximum height of the wrinkle were significantly improved in the test group. Parameters of skin elasticity, including overall elasticity, net elasticity, and biological elasticity, were also significantly improved in the test group at Week 12 as compared with the placebo group. Moreover, skin hydration and whitening parameters changed more significantly in the test group than in the placebo group. None of the participants experienced adverse events related to the test product.

Conclusions: Taken together, these findings suggest that low-molecular-weight collagen peptides supplementation can safely ehance human skin wrinkling, hydration, elasticity, and whitening properties.
Full Text
https://onlinelibrary.wiley.com/doi/10.1111/jocd.16026
Files in This Item:
T202401857.pdf Download
DOI
10.1111/jocd.16026
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Seong, Seol Hwa(성설화)
Lee, Young In(이영인) ORCID logo https://orcid.org/0000-0001-6831-7379
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
Choi, Sooyeon(최수연)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198368
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