24 47

Cited 0 times in

Impacts of Subtype on Clinical Feature and Outcome of Male Breast Cancer: Multicenter Study in Korea (KCSG BR16-09)

 Jieun Lee  ;  Keun Seok Lee  ;  Sung Hoon Sim  ;  Heejung Chae  ;  Joohyuk Sohn  ;  Gun Min Kim  ;  Kyung-Hee Lee  ;  Su Hwan Kang  ;  Kyung Hae Jung  ;  Jae-Ho Jeong  ;  Jae Ho Byun  ;  Su-Jin Koh  ;  Kyoung Eun Lee  ;  Seungtaek Lim  ;  Hee Jun Kim  ;  Hye Sung Won  ;  Hyung Soon Park  ;  Guk Jin Lee  ;  Soojung Hong  ;  Sun Kyung Baek  ;  Soon Il Lee  ;  Moon Young Choi  ;  In Sook Woo 
 CANCER RESEARCH AND TREATMENT, Vol.55(1) : 123-135, 2023-01 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms* / pathology ; Breast Neoplasms, Male* / drug therapy ; Humans ; Male ; Middle Aged ; Prognosis ; Republic of Korea / epidemiology ; Retrospective Studies ; Triple Negative Breast Neoplasms* / drug therapy
Asia ; Breast neoplasms ; Male ; Prognosis ; Type
PURPOSE: The treatment of male breast cancer (MBC) has been extrapolated from female breast cancer (FBC) because of its rarity despite their different clinicopathologic characteristics. We aimed to investigate the distribution of intrinsic subtypes based on immunohistochemistry, their clinical impact, and treatment pattern in clinical practice through a multicenter study in Korea. MATERIALS AND METHODS: We retrospectively analyzed clinical data of 248 MBC patients from 18 institutions across the country from January 1995 to July 2016. RESULTS: The median age of MBC patients was 63 years (range, 25 to 102 years). Among 148 intrinsic subtype classified patients, 61 (41.2%), 44 (29.7%), 29 (19.5%), and 14 (9.5%) were luminal A, luminal B, human epidermal growth factor receptor 2, and triple-negative breast cancer, respectively. Luminal A subtype showed trends for superior survival compared to other subtypes. Most hormone receptor-positive patients (166 patients, 82.6%) received adjuvant endocrine treatment. Five-year completion of adjuvant endocrine treatment was associated with superior disease-free survival (DFS) in patients classified with an intrinsic subtype (hazard ratio [HR], 0.15; 95% confidence interval [CI], 0.04 to 0.49; p=0.002) and in all patients (HR, 0.16; 95% CI, 0.05 to 0.54; p=0.003). CONCLUSION: Distribution of subtypes of MBC was similar to FBC and luminal type A was most common. Overall survival tended to be improved for luminal A subtype, although there was no statistical significance. Completion of adjuvant endocrine treatment was associated with prolonged DFS in intrinsic subtype classified patients. MBC patients tended to receive less treatment. MBC patients should receive standard treatment according to guidelines as FBC patients.
Files in This Item:
T999202541.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gun Min(김건민) ORCID logo https://orcid.org/0000-0001-9167-8682
Sohn, Joo Hyuk(손주혁) ORCID logo https://orcid.org/0000-0002-2303-2764
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.