24 61

Cited 17 times in

Hepatocellular Carcinoma Incidence in Alcohol-Associated Cirrhosis: Systematic Review and Meta-analysis

Authors
 Daniel Q Huang  ;  Darren J H Tan  ;  Cheng Han Ng  ;  Maral Amangurbanova  ;  Nancy Sutter  ;  Phoebe Wen Lin Tay  ;  Wen Hui Lim  ;  Jie Ning Yong  ;  Ansel Tang  ;  Nicholas Syn  ;  Mark D Muthiah  ;  Eunice X X Tan  ;  Shravan Dave  ;  Benjamin Tay  ;  Abdul M Majzoub  ;  Danielle Gerberi  ;  Beom Kyung Kim  ;  Rohit Loomba 
Citation
 CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, Vol.21(5) : 1169-1177, 2023-05 
Journal Title
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
ISSN
 1542-3565 
Issue Date
2023-05
MeSH
Carcinoma, Hepatocellular* / diagnosis ; Carcinoma, Hepatocellular* / epidemiology ; Carcinoma, Hepatocellular* / etiology ; Esophageal and Gastric Varices* / complications ; Gastrointestinal Hemorrhage / complications ; Humans ; Incidence ; Liver Cirrhosis / complications ; Liver Cirrhosis / epidemiology ; Liver Cirrhosis, Alcoholic / complications ; Liver Cirrhosis, Alcoholic / epidemiology ; Liver Neoplasms* / diagnosis ; Liver Neoplasms* / epidemiology ; Liver Neoplasms* / etiology ; Prospective Studies ; Risk Factors
Keywords
Alcohol ; Cirrhosis ; Hepatocellular Carcinoma ; Incidence
Abstract
BACKGROUND & AIMS: Alcohol is one of the leading causes of hepatocellular carcinoma (HCC). However, pooled estimates of HCC incidence in alcohol-associated cirrhosis have not been evaluated systematically. We performed a pooled analysis of time-to-event data to provide robust estimates for the incidence of HCC in alcohol-associated cirrhosis. METHODS: Medline, Embase, Cochrane Central Register, Scopus, and Web of Science were searched from inception to August 2021. Individual patient data were reconstructed from published Kaplan-Meier curves, and a pooled analysis of cumulative HCC incidence was performed using a random-effects model. RESULTS: We screened 5022 articles and included 18 studies (148,333 patients). In the pooled analysis, the cumulative incidence of HCC in alcohol-associated cirrhosis at 1, 5, and 10 years among studies that accounted for the competing risk of death without HCC was 1%, 3%, and 9%, respectively. A secondary analysis by traditional meta-analysis determined that the HCC incidence rate was higher in cohorts enrolled in a HCC surveillance program (18.6 vs 4.8 per 1000 person-years; P [ .001) vs those who were not enrolled in a surveillance program. Meta-regression showed that diabetes, smoking, variceal bleeding, and hepatic decompensation were associated with a higher risk of HCC. CONCLUSIONS: Our analysis determined that the 5- and 10-year cumulative risk of HCC in alcohol-associated cirrhosis was 3% and 9%, respectively, with a higher incidence in cohorts that were enrolled in a HCC surveillance program. These data should be validated further in large prospective studies, and may have important implications for HCC screening and surveillance among pa-tients with alcohol-associated cirrhosis.
Files in This Item:
T999202523.pdf Download
DOI
10.1016/j.cgh.2022.06.032
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198323
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links