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Consensus Statement on the Use of Near-Infrared Fluorescence Imaging during Pancreatic Cancer Surgery Based on a Delphi Study: Surgeons' Perspectives on Current Use and Future Recommendations

 Lysanne D A N de Muynck  ;  Kevin P White  ;  Adnan Alseidi  ;  Elisa Bannone  ;  Luigi Boni  ;  Michael Bouvet  ;  Massimo Falconi  ;  Hans F Fuchs  ;  Michael Ghadimi  ;  Ines Gockel  ;  Thilo Hackert  ;  Takeaki Ishizawa  ;  Chang Moo Kang  ;  Norihiro Kokudo  ;  Felix Nickel  ;  Stefano Partelli  ;  Elena Rangelova  ;  Rutger Jan Swijnenburg  ;  Fernando Dip  ;  Raul J Rosenthal  ;  Alexander L Vahrmeijer  ;  J Sven D Mieog 
 CANCERS, Vol.15(3) : 652, 2023-01 
Journal Title
Issue Date
Delphi ; cancer surgery ; consensus ; fluorescence-guided surgery ; indocyanine green ; intraoperative imaging ; near-infrared fluorescence ; pancreatic cancer
Indocyanine green (ICG) is one of the only clinically approved near-infrared (NIR) fluorophores used during fluorescence-guided surgery (FGS), but it lacks tumor specificity for pancreatic ductal adenocarcinoma (PDAC). Several tumor-targeted fluorescent probes have been evaluated in PDAC patients, yet no uniformity or consensus exists among the surgical community on the current and future needs of FGS during PDAC surgery. In this first-published consensus report on FGS for PDAC, expert opinions were gathered on current use and future recommendations from surgeons’ perspectives. A Delphi survey was conducted among international FGS experts via Google Forms. Experts were asked to anonymously vote on 76 statements, with ≥70% agreement considered consensus and ≥80% participation/statement considered vote robustness. Consensus was reached for 61/76 statements. All statements were considered robust. All experts agreed that FGS is safe with few drawbacks during PDAC surgery, but that it should not yet be implemented routinely for tumor identification due to a lack of PDAC-specific NIR tracers and insufficient evidence proving FGS’s benefit over standard methods. However, aside from tumor imaging, surgeons suggest they would benefit from visualizing vasculature and surrounding anatomy with ICG during PDAC surgery. Future research could also benefit from identifying neuroendocrine tumors. More research focusing on standardization and combining tumor identification and vital-structure imaging would greatly improve FGS’s use during PDAC surgery. © 2023 by the authors.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Chang Moo(강창무) ORCID logo https://orcid.org/0000-0002-5382-4658
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