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Conductive Thread-Based Immunosensor for Pandemic Influenza A (H1N1) Virus Detection

Authors
 Seong Uk Son  ;  Soojin Jang  ;  Jaewoo Lim  ;  Seung Beom Seo  ;  Taejoon Kang  ;  Juyeon Jung  ;  Seo Yeong Oh  ;  Sun-Woo Yoon  ;  Dongeun Yong  ;  Jaejong Lee  ;  Eun-Kyung Lim 
Citation
 ACS APPLIED MATERIALS & INTERFACES, Vol.15(6) : 7759-7766, 2023-02 
Journal Title
ACS APPLIED MATERIALS & INTERFACES
ISSN
 1944-8244 
Issue Date
2023-02
MeSH
Antibodies ; Biosensing Techniques* ; Humans ; Immunoassay ; Influenza A Virus, H1N1 Subtype* ; Influenza, Human* / diagnosis
Keywords
conductive thread ; electric immunosensor ; pH1N1 virus ; point-of-care detection ; respiratory infection
Abstract
Infectious agents such as viruses pose significant threats to human health, being transmitted via direct contact as well as airborne transmission without direct contact, thus requiring rapid detection to prevent the spread of infectious diseases. In this study, we developed a conductive thread-based immunosensor (CT-IS), a biosensor to easily detect the presence of airborne viruses. CT-IS utilizes an antibody that specifically recognizes the HA protein of the pandemic influenza A (pH1N1) virus, which is incorporated into the conductive thread. The antigen-antibody interaction results in increased strain on the conductive thread in the presence of the pH1N1 virus, resulting in increased electrical resistance of the CT-IS. We evaluated the performance of this sensor using the HA protein and the pH1N1 virus, in addition to samples from patients infected with the pH1N1 virus. We observed a significant change in resistance in the pH1N1-infected patient samples (positive: n = 11, negative: n = 9), whereas negligible change was observed in the control samples (patients not infected with the pH1N1 virus; negative). Hence, the CT-IS is a lightweight fiber-type sensor that can be used as a wearable biosensor by combining it with textiles, to detect the pH1N1 virus in a person’s vicinity. © 2023 American Chemical Society.
Full Text
https://pubs.acs.org/doi/10.1021/acsami.2c19403
DOI
10.1021/acsami.2c19403
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198238
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