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Comparison of low-density lipoprotein cholesterol estimation methods in individuals with insulin resistance: A cross-sectional study

Authors
 Han-Joon Bae  ;  Sung-Woo Kim  ;  In-Soo Kim 
Citation
 CLINICA CHIMICA ACTA, Vol.547 : 117393, 2023-07 
Journal Title
CLINICA CHIMICA ACTA
ISSN
 0009-8981 
Issue Date
2023-07
MeSH
Adult ; Cholesterol, LDL ; Cross-Sectional Studies ; Female ; Humans ; Insulin ; Insulin Resistance* ; Male ; Middle Aged ; Nutrition Surveys ; Triglycerides
Keywords
Atherosclerosis ; Cholesterol ; Friedewald equation ; Low-density lipoprotein ; Martin-Hopkins equation ; Sampson equation
Abstract
Background and aims: The Friedewald, Sampson, and Martin equations were developed to estimate low-density lipoprotein cholesterol levels; however, the validation data of these equations with and without insulin resis-tance are insufficient.Materials and methods: We collected data on low-density lipoprotein cholesterol and lipid profiles from the Korea National Health and Nutrition Examination Survey. Using the data on insulin requirement, insulin resistance was calculated for 4,351 participants (median age, 48 [36-59] years; 49.9% male) using the homeostatic model assessment for insulin resistance (n = 2,713) and quantitative insulin-sensitivity check index (n = 2,400).Results: According to the mean and median absolute deviation, the Martin equation yielded more accurate es-timates than other equations when the triglyceride level was < 400 mg/dL with insulin resistance; the Sampson equation yielded lower estimates when the direct low-density lipoprotein cholesterol level was < 70 mg/dL and triglyceride level was < 400 mg/dL without insulin resistance. However, the three equations yielded similar estimates when the triglyceride level was < 150 mg/dL with and without insulin resistance.Conclusion: The Martin equation yielded more appropriate estimates than the Friedewald and Sampson equations for triglyceride levels < 400 mg/dL with and without insulin resistance. If the triglyceride level was < 150 mg, the Friedewald equation could also be considered.
Full Text
https://www.sciencedirect.com/science/article/pii/S000989812300195X
DOI
10.1016/j.cca.2023.117393
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, In-Soo(김인수) ORCID logo https://orcid.org/0000-0003-2801-5514
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198234
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