27 45

Cited 3 times in

Change in Severity and Clinical Manifestation of MIS-C Over SARS-CoV-2 Variant Outbreaks in Korea

 Young June Choe  ;  Eun Hwa Choi  ;  Jong Woon Choi  ;  Byung Wook Eun  ;  Lucy Youngmin Eun  ;  Yae-Jean Kim  ;  Yeo Hyang Kim  ;  Young A Kim  ;  Yun-Kyung Kim  ;  Ji Hee Kwak  ;  Hyukmin Lee  ;  June Dong Park  ;  Yeon Haw Jung  ;  Jin Gwack  ;  Sangwon Lee  ;  MIS-C Surveillance Group 
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.38(30) : e225, 2023-07 
Journal Title
Issue Date
COVID-19* / epidemiology ; Child ; Disease Outbreaks ; Humans ; Republic of Korea / epidemiology ; SARS-CoV-2*
BACKGROUND: There is difference in the incidence of multi-system inflammatory syndrome in children (MIS-C) in patients with different variants of severe acute respiratory syndrome coronavirus 2, however, little is known about the epidemiology in Asian countries. We investigated and compared the epidemiology of the MIS-C during omicron-dominant period with that of previous periods in South Korea. METHODS: We obtained clinical, epidemiological and laboratory data on MIS-C cases from national MIS-C surveillance in South Korea. We defined pre-delta period as January 2020-May 2021; delta period as June 2021-December 2021; and omicron period as January 2022-April 2022. We describe the clinical characteristics and outcomes of MIS-C patients by period. RESULTS: A total of 91 cases were assessed to be MIS-C cases. Number of MIS-C cases have increased from six cases during pre-delta period to 66 cases during omicron period, while the incidence rate (the number of MIS-C cases per 100,000 cases of reported coronavirus disease 2019) has decreased from 38.5 cases per 100,000 (95% confidence interval [CI], 14.1-83.9) during pre-delta period to 1.6 cases per 100,000 (95% CI, 1.2-2.0) during omicron periods. During pre-delta period, 66.7% and 100% had hypotension and gastrointestinal involvement, respectively; while during omicron period, 12.1% and 6.1% had such clinical manifestations. Fifty percent of pre-delta MIS-C patients were taken intensive care unit (ICU) cares, while 10.6% of patients during omicron periods were in ICUs. CONCLUSION: Omicron period were associated with less severe clinical manifestation compared to pre-delta and delta periods. Although incidence rate of MIS-C was lower for the omicron period than pre-delta and delta periods, number of patients reported with MIS-C may pose a substantial clinical burden. © 2023 The Korean Academy of Medical Sciences.
Files in This Item:
T999202406.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Eun, Lucy Youngmin(은영민) ORCID logo https://orcid.org/0000-0002-4577-3168
Lee, Hyuk Min(이혁민) ORCID logo https://orcid.org/0000-0002-8523-4126
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.