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A Multicenter, Prospective, Observational Study to Evaluate Ethanol-Induced Symptoms in Patients Receiving Docetaxel Chemotherapy

Authors
 Young-Woong Won  ;  Jin-Hyoung Kang  ;  Jung Hye Kwon  ;  Dong-Hoe Koo  ;  Jung Hun Kang  ;  Chi Hoon Maeng  ;  Hee Kyung Ahn  ;  Sung Yong Oh  ;  Dae-Won Lee  ;  Joohyuk Sohn  ;  So Yeon Oh  ;  Kyung Hee Lee  ;  Su-Jin Koh  ;  Keun Seok Lee  ;  Chan-Kyu Kim  ;  Ji-Yeon Kim  ;  Jun Ho Ji  ;  Sung-Bae Kim  ;  Joo Young Ha  ;  Ho Young Kim 
Citation
 CANCER RESEARCH AND TREATMENT, Vol.55(4) : 1096-1103, 2023-10 
Journal Title
CANCER RESEARCH AND TREATMENT
ISSN
 1598-2998 
Issue Date
2023-10
MeSH
Antineoplastic Agents* / adverse effects ; Antineoplastic Combined Chemotherapy Protocols / therapeutic use ; Breast Neoplasms* / drug therapy ; Docetaxel / adverse effects ; Ethanol / adverse effects ; Female ; Humans ; Patients ; Prospective Studies
Keywords
Chemotherapy ; Docetaxel ; Ethanol
Abstract
Purpose Several previous studies and case reports have reported ethanol-induced symptoms in patients receiving anticancer drugs containing ethanol. Most docetaxel formulations contain ethanol as a solvent. However, there are insufficient data on ethanol-induced symptoms when docetaxel-containing ethanol is administered. The primary purpose of this study was to investigate the frequency and pattern of ethanol-induced symptoms during and after docetaxel administration. The secondary purpose was to explore the risk factors for ethanol-induced symptoms.
Materials and Methods This was a prospective, multicenter, observational study. The participants filled out ethanol-induced symptom questionnaire on the day of chemotherapy and the following day.
Results Data from 451 patients were analyzed. The overall occurrence rate of ethanol-induced symptoms was 44.3% (200/451 patients). The occurrence rate of facial flushing was highest at 19.7% (89/451 patients), followed by nausea in 18.2% (82/451 patients), and dizziness in 17.5% (79/451 patients). Although infrequent, unsteady walking and impaired balance occurred in 4.2% and 3.3% of patients, respectively. Female sex, presence of underlying disease, younger age, docetaxel dose, and docetaxel-containing ethanol amount were significantly associated with the occurrence of ethanol-induced symptoms.
Conclusion The occurrence of ethanol-induced symptoms was not low in patients receiving docetaxel-containing ethanol. Physicians need to pay more attention to the occurrence of ethanol-induced symptoms and prescribe ethanol-free or low-ethanol-containing formulations to high-risk patients.
Files in This Item:
T999202352.pdf Download
DOI
10.4143/crt.2022.1565
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Joo Hyuk(손주혁) ORCID logo https://orcid.org/0000-0002-2303-2764
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198155
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