Cited 3 times in
How early can atherosclerosis be detected by coronary CT angiography? Insights from quantitative CT analysis of serial scans in the PARADIGM trial
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 성지민 | - |
dc.contributor.author | 이병권 | - |
dc.contributor.author | 장혁재 | - |
dc.date.accessioned | 2024-02-15T06:59:28Z | - |
dc.date.available | 2024-02-15T06:59:28Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 1934-5925 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198105 | - |
dc.description.abstract | Background: Non-obstructing small coronary plaques may not be well recognized by expert readers during coronary computed tomography angiography (CCTA) evaluation. Recent developments in atherosclerosis imaging quantitative computed tomography (AI-QCT) enabled by machine learning allow for whole-heart coronary phenotyping of atherosclerosis, but its diagnostic role for detection of small plaques on CCTA is unknown. Methods: We performed AI-QCT in patients who underwent serial CCTA in the multinational PARADIGM study. AI-QCT results were verified by a level III experienced reader, who was blinded to baseline and follow-up status of CCTA. This retrospective analysis aimed to characterize small plaques on baseline CCTA and evaluate their serial changes on follow-up imaging. Small plaques were defined as a total plaque volume <50 mm3. Results: A total of 99 patients with 502 small plaques were included. The median total plaque volume was 6.8 mm3 (IQR 3.5-13.9 mm3), most of which was non-calcified (median 6.2 mm3; 2.9-12.3 mm3). The median age at the time of baseline CCTA was 61 years old and 63% were male. The mean interscan period was 3.8 ± 1.6 years. On follow-up CCTA, 437 (87%) plaques were present at the same location as small plaques on baseline CCTA; 72% were larger and 15% decreased in volume. The median total plaque volume and non-calcified plaque volume increased to 18.9 mm3 (IQR 8.3-45.2 mm3) and 13.8 mm3 (IQR 5.7-33.4 mm3), respectively, among plaques that persisted on follow-up CCTA. Small plaques no longer visualized on follow-up CCTA were significantly more likely to be of lower volume, shorter in length, non-calcified, and more distal in the coronary artery, as compared with plaques that persisted at follow-up. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Atherosclerosis* | - |
dc.subject.MESH | Computed Tomography Angiography / methods | - |
dc.subject.MESH | Coronary Angiography / methods | - |
dc.subject.MESH | Coronary Artery Disease* / diagnostic imaging | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Plaque, Atherosclerotic* | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Tomography, X-Ray Computed / methods | - |
dc.title | How early can atherosclerosis be detected by coronary CT angiography? Insights from quantitative CT analysis of serial scans in the PARADIGM trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Research Institute (부설연구소) | - |
dc.contributor.googleauthor | Rhanderson Cardoso | - |
dc.contributor.googleauthor | Andrew D Choi | - |
dc.contributor.googleauthor | Arthur Shiyovich | - |
dc.contributor.googleauthor | Stephanie A Besser | - |
dc.contributor.googleauthor | James K Min | - |
dc.contributor.googleauthor | James Earls | - |
dc.contributor.googleauthor | Daniele Andreini | - |
dc.contributor.googleauthor | Mouaz H Al-Mallah | - |
dc.contributor.googleauthor | Matthew J Budoff | - |
dc.contributor.googleauthor | Filippo Cademartiri | - |
dc.contributor.googleauthor | Kavitha Chinnaiyan | - |
dc.contributor.googleauthor | Jung Hyun Choi | - |
dc.contributor.googleauthor | Eun Ju Chun | - |
dc.contributor.googleauthor | Edoardo Conte | - |
dc.contributor.googleauthor | Ilan Gottlieb | - |
dc.contributor.googleauthor | Martin Hadamitzky | - |
dc.contributor.googleauthor | Yong-Jin Kim | - |
dc.contributor.googleauthor | Byoung Kwon Lee | - |
dc.contributor.googleauthor | Jonathon A Leipsic | - |
dc.contributor.googleauthor | Erica Maffei | - |
dc.contributor.googleauthor | Hugo Marques | - |
dc.contributor.googleauthor | Pedro de Araújo Gonçalves | - |
dc.contributor.googleauthor | Gianluca Pontone | - |
dc.contributor.googleauthor | Sang-Eun Lee | - |
dc.contributor.googleauthor | Ji Min Sung | - |
dc.contributor.googleauthor | Renu Virmani | - |
dc.contributor.googleauthor | Habib Samady | - |
dc.contributor.googleauthor | Fay Y Lin | - |
dc.contributor.googleauthor | Peter H Stone | - |
dc.contributor.googleauthor | Daniel S Berman | - |
dc.contributor.googleauthor | Jagat Narula | - |
dc.contributor.googleauthor | Leslee J Shaw | - |
dc.contributor.googleauthor | Jeroen J Bax | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.contributor.googleauthor | Ron Blankstein | - |
dc.identifier.doi | 10.1016/j.jcct.2023.08.012 | - |
dc.contributor.localId | A01955 | - |
dc.contributor.localId | A02793 | - |
dc.contributor.localId | A03490 | - |
dc.relation.journalcode | J01291 | - |
dc.identifier.eissn | 1876-861X | - |
dc.identifier.pmid | 37798157 | - |
dc.subject.keyword | Artificial intelligence | - |
dc.subject.keyword | Atherosclerosis | - |
dc.subject.keyword | Coronary | - |
dc.subject.keyword | Coronary CT angiography | - |
dc.subject.keyword | Small plaque | - |
dc.contributor.alternativeName | Sung, Ji Min | - |
dc.contributor.affiliatedAuthor | 성지민 | - |
dc.contributor.affiliatedAuthor | 이병권 | - |
dc.contributor.affiliatedAuthor | 장혁재 | - |
dc.citation.volume | 17 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 407 | - |
dc.citation.endPage | 412 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, Vol.17(6) : 407-412, 2023-11 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.