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Margin-negative minimally invasive pancreatoduodenectomy following FOLFIRINOX neoadjuvant chemotherapy in invasive intraductal papillary mucinous neoplasm of pancreas: a case report

Authors
 Jinho Kim  ;  Seokjin Park  ;  Eunsang Yim  ;  Su Hyeong Park  ;  Chang Moo Kang 
Citation
 Korean Journal of Clinical Oncology (대한임상종양학회지), Vol.19(2) : 80-83, 2023-12 
Journal Title
Korean Journal of Clinical Oncology(대한임상종양학회지)
ISSN
 1738-8082 
Issue Date
2023-12
Keywords
Neoadjuvant chemotherapy ; Pancreatic intraductal neopla는 ; Minimally invasive surgery ; Pancreatoduodenectomy
Abstract
This study shows a case of neoadjuvant chemotherapy application for the management of a 34-year-old male patient diagnosed with invasive intraductal papillary mucinous neoplasm (IPMN), for which curative margin-negative resection initially seemed challenging. Five cycles of the FOLFIRINOX regimen (5-fluorouracil, leucovorin, irinotecan, and oxaliplatin) were administered preoperatively, resulting in a significant reduction of the intraductal mass size and deformity of the main vessels. The patient subsequently underwent a successful robotic pylorus-preserving pancreatoduodenectomy. Postoperatively, the patient received adjuvant chemotherapy with FOLFIRINOX, and after 5 months, showed no signs of tumor recurrence or specific complications. These findings suggest that neoadjuvant therapy can be a potentially effective strategy even in advanced invasive IPMN. Further research is necessary to establish guidelines for its application.
Files in This Item:
T202400869.pdf Download
DOI
10.14216/kjco.23014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Chang Moo(강창무) ORCID logo https://orcid.org/0000-0002-5382-4658
Kim, Jin Ho(김진호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198079
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