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Low Muscle and High Fat Percentages Are Associated with Low Natural Killer Cell Activity: A Cross-Sectional Study
DC Field | Value | Language |
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dc.contributor.author | 조아라 | - |
dc.date.accessioned | 2024-02-15T06:47:28Z | - |
dc.date.available | 2024-02-15T06:47:28Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198037 | - |
dc.description.abstract | This study aimed to investigate whether body fat and muscle percentages are associated with natural killer cell activity (NKA). This was a cross-sectional study, conducted on 8058 subjects in a medical center in Korea. The association between the muscle and fat percentage tertiles and a low NKA, defined as an interferon-gamma level lower than 500 pg/mL, was assessed. In both men and women, the muscle mass and muscle percentage were significantly low in participants with a low NKA, whereas the fat percentage, white blood cell count, and C-reactive protein (CRP) level were significantly high in those with a low NKA. Compared with the lowest muscle percentage tertile as a reference, the fully adjusted odd ratios (ORs) (95% confidence intervals (CIs)) for a low NKA were significantly lower in T2 (OR: 0.69; 95% CI: 0.55-0.86) and T3 (OR: 0.74; 95% CI: 0.57-0.95) of men, and T3 (OR: 0.76; 95% CI: 0.59-0.99) of women. Compared with the lowest fat percentage tertile as a reference, the fully adjusted OR was significantly higher in T3 of men (OR: 1.31; 95% CI: 1.01-1.69). A high muscle percentage was significantly inversely associated with a low NKA in men and women, whereas a high fat percentage was significantly associated with a low NKA in men. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adipose Tissue* | - |
dc.subject.MESH | Body Composition / physiology | - |
dc.subject.MESH | Body Mass Index | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Killer Cells, Natural | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Muscles* | - |
dc.title | Low Muscle and High Fat Percentages Are Associated with Low Natural Killer Cell Activity: A Cross-Sectional Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | A-Ra Cho | - |
dc.contributor.googleauthor | Eunkyung Suh | - |
dc.contributor.googleauthor | Hyoju Oh | - |
dc.contributor.googleauthor | Baek Hwan Cho | - |
dc.contributor.googleauthor | Minchan Gil | - |
dc.contributor.googleauthor | Yun-Kyong Lee | - |
dc.identifier.doi | 10.3390/ijms241512505 | - |
dc.contributor.localId | A05183 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.pmid | 37569879 | - |
dc.subject.keyword | body composition | - |
dc.subject.keyword | fat percentage | - |
dc.subject.keyword | innate immunity | - |
dc.subject.keyword | muscle percentage | - |
dc.subject.keyword | natural killer cell activity | - |
dc.subject.keyword | obesity | - |
dc.contributor.alternativeName | Cho A Ra | - |
dc.contributor.affiliatedAuthor | 조아라 | - |
dc.citation.volume | 24 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 12505 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.24(15) : 12505, 2023-08 | - |
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