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Surgical Treatment of Epilepsy with Bilateral MRI Abnormalities

Authors
 Hui Jin Shin  ;  Se Hee Kim  ;  Hoon-Chul Kang  ;  Joon Soo Lee  ;  Heung Dong Kim 
Citation
 WORLD NEUROSURGERY, Vol.180 : e37-e45, 2023-12 
Journal Title
WORLD NEUROSURGERY
ISSN
 1878-8750 
Issue Date
2023-12
MeSH
Adolescent ; Child ; Drug Resistant Epilepsy* / diagnostic imaging ; Drug Resistant Epilepsy* / pathology ; Drug Resistant Epilepsy* / surgery ; Electroencephalography / methods ; Epilepsy* / diagnostic imaging ; Epilepsy* / pathology ; Epilepsy* / surgery ; Humans ; Magnetic Resonance Imaging ; Retrospective Studies ; Seizures / surgery ; Treatment Outcome
Keywords
Drug-resistant epilepsy ; Epilepsy surgery ; Magnetic resonance imaging
Abstract
Objective: To investigate the surgical outcomes of patients with drug-resistant epilepsy and bilateral brain magnetic resonance imaging (MRI) abnormalities who had undergone various epilepsy surgeries.

Methods: Patients with drug-resistant epilepsy and bilateral brain abnormalities on MRI who underwent epilepsy surgery at the Severance Children's Hospital between October 2003 and December 2021 were included. The age of seizure onset was 18 years or younger. Engel's classification was used to assess seizure outcomes at 1, 2, and 5 years after surgery.

Results: A total of 40 patients met the inclusion criteria. The median age at surgery was 10.9 years (interquartile range [IQR] 6.9-15.1); the median interval to surgery was 7.1 years (IQR 2.7-11.5). One year after surgery, a favorable outcome of Engel class I-II was observed in 53% (21/40) of patients. At the 2- and 5-year follow-ups, 56% (20/36) and 63% (17/27) of patients showed good postoperative outcomes, respectively.

Conclusions: Approximately, half of the patients with bilateral brain MRI abnormalities achieved seizure freedom after epilepsy surgery. The existence of bilateral brain MRI abnormalities should not hinder resective epilepsy surgery.
Full Text
https://www.sciencedirect.com/science/article/pii/S1878875023010021
DOI
10.1016/j.wneu.2023.07.062
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hoon Chul(강훈철) ORCID logo https://orcid.org/0000-0002-3659-8847
Kim, Se Hee(김세희) ORCID logo https://orcid.org/0000-0001-7773-1942
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
Shin, Hui Jin(신희진) ORCID logo https://orcid.org/0000-0002-1541-2564
Lee, Joon Soo(이준수) ORCID logo https://orcid.org/0000-0001-9036-9343
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198031
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