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Hydyothermally treated coral scaffold promotes prolifertion of mesenchymal stem cells and enhances segmental bone defect healing
DC Field | Value | Language |
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dc.contributor.author | 문홍석 | - |
dc.contributor.author | 박영범 | - |
dc.contributor.author | 박재한 | - |
dc.contributor.author | 조성원 | - |
dc.date.accessioned | 2024-02-15T06:32:14Z | - |
dc.date.available | 2024-02-15T06:32:14Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197947 | - |
dc.description.abstract | Introduction: Synthetic hydroxyapatite (HAp) scaffolds have shown promising therapeutic outcomes in both animals and patients. In this study, we aim to evaluate the chemical and physical phenotype, biocompatibility, and bone repair effects of hydrothermally treated coral with natural coral and synthetic HAp. Methods: The phase composition, surface pattern, 3D structures, and porosity of the scaffolds were characterized, and cell viability, proliferation, and osteogenic differentiation of mesenchymal stem cells (MSCs) after seeding onto the scaffold were determined. The scaffolds were implanted into rats to assess their bone repair effects using micro-CT analysis, mechanical testing, and histological staining. Results: The results showed that the phase composition, porous structure, and porosity of hydrothermally treated coral were comparable to pure HAp scaffold. While only the natural coral happens to be dominantly calcium carbonate. Higher cell proliferation and osteogenic differentiation potential were observed in the hydrothermally treated coral scaffold compared to natural coral and pure HAp. Histological results also showed increased new bone formation in the hydrothermally treated coral group. Discussion: Overall, our study suggests that hydrothermal modification enhances the cytocompatibility and therapeutic capacity of coral without altering its physical properties, showing superior effectiveness in bone repair to synthetic HAp. Copyright © 2023 Huang, Park, Jung, Moon, Zong, Li, Lin, Cho and Park. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Frontiers Media S.A. | - |
dc.relation.isPartOf | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Hydyothermally treated coral scaffold promotes prolifertion of mesenchymal stem cells and enhances segmental bone defect healing | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Prosthodontics (보철과학교실) | - |
dc.contributor.googleauthor | Jianping Huang | - |
dc.contributor.googleauthor | Jaehan Park | - |
dc.contributor.googleauthor | Narae Jung | - |
dc.contributor.googleauthor | Hong Seok Moon | - |
dc.contributor.googleauthor | Zhixian Zong | - |
dc.contributor.googleauthor | Gang Li | - |
dc.contributor.googleauthor | Sien Lin | - |
dc.contributor.googleauthor | Sung-Won Cho | - |
dc.contributor.googleauthor | Youngbum Park | - |
dc.identifier.doi | 10.3389/fbioe.2023.1332138 | - |
dc.contributor.localId | A01395 | - |
dc.contributor.localId | A01567 | - |
dc.contributor.localId | A06341 | - |
dc.contributor.localId | A03837 | - |
dc.relation.journalcode | J04157 | - |
dc.identifier.eissn | 2296-4185 | - |
dc.identifier.pmid | 38173870 | - |
dc.subject.keyword | bone defect coralline materials | - |
dc.subject.keyword | hydrothermal modification | - |
dc.subject.keyword | hydroxyapatite | - |
dc.subject.keyword | mesenchymal stem cells | - |
dc.contributor.alternativeName | Moon, Hong Seok | - |
dc.contributor.affiliatedAuthor | 문홍석 | - |
dc.contributor.affiliatedAuthor | 박영범 | - |
dc.contributor.affiliatedAuthor | 박재한 | - |
dc.contributor.affiliatedAuthor | 조성원 | - |
dc.citation.volume | 11 | - |
dc.citation.startPage | 1332138 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, Vol.11 : 1332138, 2023-12 | - |
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