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Weight loss and risk of dementia in individuals with versus without obesity

Authors
 Keun You Kim  ;  Junghee Ha  ;  Jun-Young Lee  ;  Eosu Kim 
Citation
 ALZHEIMERS & DEMENTIA, Vol.19(12) : 5471-5481, 2023-12 
Journal Title
ALZHEIMERS & DEMENTIA
ISSN
 1552-5260 
Issue Date
2023-12
MeSH
Aged ; Alzheimer Disease* / complications ; Alzheimer Disease* / epidemiology ; Body Mass Index ; Humans ; Obesity / complications ; Obesity / epidemiology ; Risk Factors ; Waist Circumference ; Weight Loss ; Related infor
Keywords
Alzheimer's disease ; body mass index ; dementia ; obesity ; waist circumference ; weight loss
Abstract
INTRODUCTION: Using nationwide cohort data, we aimed to elucidate whether baseline obesity altered the relationship between loss in body mass index (BMI) or waist circumference (WC) and risk of dementia. METHODS: Among 9689 participants whose BMIs and WCs were repeatedly measured over 1 year, 1:1 propensity score matching was conducted between participants with and without obesity (n = 2976 per group, mean age 70.9). For each group, we explored the association between loss in BMI, or WC, and incidence of dementia during an approximately 4-year follow-up period. RESULTS: BMI loss was associated with an increased risk of all-cause dementia and Alzheimer's disease in participants without obesity; however, this association was absent in participants with obesity. WC loss was associated with decreased Alzheimer's disease risk only in participants with obesity. DISCUSSION: Only unfavorable loss (loss from non-obese state) in BMI, not WC, can be a metabolic biomarker of prodromal dementia.
Full Text
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13155
DOI
10.1002/alz.13155
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Keun You(김근유) ORCID logo https://orcid.org/0000-0001-7192-2828
Kim, Eosu(김어수) ORCID logo https://orcid.org/0000-0001-9472-9465
Ha, Junghee(하정희) ORCID logo https://orcid.org/0000-0002-4217-3570
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197909
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