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Targeting dysregulated lipid metabolism in the tumor microenvironment
DC Field | Value | Language |
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dc.contributor.author | 송나영 | - |
dc.date.accessioned | 2024-01-16T01:57:39Z | - |
dc.date.available | 2024-01-16T01:57:39Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197799 | - |
dc.description.abstract | The reprogramming of lipid metabolism and its association with oncogenic signaling pathways within the tumor microenvironment (TME) have emerged as significant hallmarks of cancer. Lipid metabolism is defined as a complex set of molecular processes including lipid uptake, synthesis, transport, and degradation. The dysregulation of lipid metabolism is affected by enzymes and signaling molecules directly or indirectly involved in the lipid metabolic process. Regulation of lipid metabolizing enzymes has been shown to modulate cancer development and to avoid resistance to anticancer drugs in tumors and the TME. Because of this, understanding the metabolic reprogramming associated with oncogenic progression is important to develop strategies for cancer treatment. Recent advances provide insight into fundamental mechanisms and the connections between altered lipid metabolism and tumorigenesis. In this review, we explore alterations to lipid metabolism and the pivotal factors driving lipid metabolic reprogramming, which exacerbate cancer progression. We also shed light on the latest insights and current therapeutic approaches based on small molecular inhibitors and phytochemicals targeting lipid metabolism for cancer treatment. Further investigations are worthwhile to fully understand the underlying mechanisms and the correlation between altered lipid metabolism and carcinogenesis. © 2023, The Author(s). | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Pharmaceutical Society of Korea | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Antineoplastic Agents* / pharmacology | - |
dc.subject.MESH | Antineoplastic Agents* / therapeutic use | - |
dc.subject.MESH | Carcinogenesis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lipid Metabolism | - |
dc.subject.MESH | Lipids | - |
dc.subject.MESH | Neoplasms* / pathology | - |
dc.subject.MESH | Tumor Microenvironment | - |
dc.title | Targeting dysregulated lipid metabolism in the tumor microenvironment | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학교실) | - |
dc.contributor.googleauthor | Do-Hee Kim | - |
dc.contributor.googleauthor | Na-Young Song | - |
dc.contributor.googleauthor | Hyungshin Yim | - |
dc.identifier.doi | 10.1007/s12272-023-01473-y | - |
dc.contributor.localId | A05713 | - |
dc.relation.journalcode | J00229 | - |
dc.identifier.pmid | 38060103 | - |
dc.subject.keyword | Cholesterol transport | - |
dc.subject.keyword | Lipid uptake | - |
dc.subject.keyword | Lipogenesis | - |
dc.subject.keyword | Lipolysis | - |
dc.subject.keyword | Phytochemical | - |
dc.subject.keyword | Tumor microenvironment | - |
dc.contributor.alternativeName | Song, Na-Young | - |
dc.contributor.affiliatedAuthor | 송나영 | - |
dc.citation.volume | 46 | - |
dc.citation.number | 11-12 | - |
dc.citation.startPage | 855 | - |
dc.citation.endPage | 881 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, Vol.46(11-12) : 855-881, 2023-12 | - |
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