Cited 3 times in
B cell responses to membrane-presented antigens require the function of the mechanosensitive cation channel Piezo1
DC Field | Value | Language |
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dc.contributor.author | 곽기혁 | - |
dc.date.accessioned | 2024-01-16T01:46:54Z | - |
dc.date.available | 2024-01-16T01:46:54Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 1937-9145 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197736 | - |
dc.description.abstract | The demand for a vaccine for coronavirus disease 2019 (COVID-19) highlighted gaps in our understanding of the requirements for B cell responses to antigens, particularly to membrane-presented antigens, as occurs in vivo. We found that human B cell responses to membrane-presented antigens required the function of Piezo1, a plasma membrane mechanosensitive cation channel. Simply making contact with a glass probe induced calcium (Ca2+) fluxes in B cells that were blocked by the Piezo1 inhibitor GsMTx4. When placed on glass surfaces, the plasma membrane tension of B cells increased, which stimulated Ca2+ influx and spreading of B cells over the glass surface, which was blocked by the Piezo1 inhibitor OB-1. B cell responses to membrane-presented antigens but not to soluble antigens were inhibited both by Piezo1 inhibitors and by siRNA-mediated knockdown of Piezo1. Thus, the activation of Piezo1 defines an essential event in B cell activation to membrane-presented antigens that may be exploited to improve the efficacy of vaccines. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.relation.isPartOf | SCIENCE SIGNALING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | B-Lymphocytes | - |
dc.subject.MESH | COVID-19* | - |
dc.subject.MESH | Cations | - |
dc.subject.MESH | Cell Membrane | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymphocyte Activation | - |
dc.title | B cell responses to membrane-presented antigens require the function of the mechanosensitive cation channel Piezo1 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Kihyuck Kwak | - |
dc.contributor.googleauthor | Haewon Sohn | - |
dc.contributor.googleauthor | Rachel George | - |
dc.contributor.googleauthor | Charles Torgbor | - |
dc.contributor.googleauthor | Javier Manzella-Lapeira | - |
dc.contributor.googleauthor | Joseph Brzostowski | - |
dc.contributor.googleauthor | Susan K Pierce | - |
dc.identifier.doi | 10.1126/scisignal.abq5096 | - |
dc.contributor.localId | A06405 | - |
dc.relation.journalcode | J02644 | - |
dc.identifier.eissn | 1945-0877 | - |
dc.identifier.pmid | 37751477 | - |
dc.contributor.alternativeName | Kwak, Kihyuck | - |
dc.contributor.affiliatedAuthor | 곽기혁 | - |
dc.citation.volume | 16 | - |
dc.citation.number | 804 | - |
dc.citation.startPage | eabq5096 | - |
dc.identifier.bibliographicCitation | SCIENCE SIGNALING, Vol.16(804) : eabq5096, 2023-09 | - |
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