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Dopamine receptor 1 on CaMKII-positive neurons within claustrum mediates adolescent cocaine exposure-induced anxiety-like behaviors and electro-acupuncture therapy

Authors
 Liying Chen  ;  Zhaoyu Liu  ;  Ziheng Zhao  ;  Demin Du  ;  Weichao Pan  ;  Xiaoyan Wei  ;  Jiaxun Nie  ;  Feifei Ge  ;  Jianhua Ding  ;  Yu Fan  ;  Hee Young Kim  ;  Xiaowei Guan 
Citation
 THERANOSTICS, Vol.13(10) : 3149-3164, 2023-05 
Journal Title
THERANOSTICS
Issue Date
2023-05
MeSH
Animals ; Anxiety / chemically induced ; Anxiety / therapy ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism ; Claustrum* / metabolism ; Cocaine* / metabolism ; Cocaine* / pharmacology ; Male ; Mice ; Neurons / metabolism ; Receptors, Dopamine D1 / metabolism
Keywords
Adolescent cocaine exposure ; Anxiety ; Claustrum ; D1RCaMKII ; Electro-acupuncture
Abstract
Adolescent cocaine exposure (ACE) increases risk of developing psychiatric problems such as anxiety, which may drive relapse in later life, however, its underlying molecular mechanism remains poorly understood.

Methods: ACE male mice model were established by exposing to cocaine during adolescent period. Elevated plus maze (EPM) were used to assess anxiety-like behaviors in mice. Within claustrum, local injection of SCH-23390, a specific antagonist for dopamine receptor 1 (D1R), or D1R knocking-down virus were used to regulate D1R function or expression on CaMKII-positive neurons (D1RCaMKII) in vivo. Electro-acupuncture (EA) treatment was performed at acupoints of Baihui and Yintang during withdrawal period.

Results: We found that ACE mice exhibited anxiety-like behaviors, along with more activated CaMKII-positive neurons and increased D1RCaMKII levels in claustrum during adulthood. Inhibiting D1R function or knocking-down D1RCaMKII levels in claustrum efficiently reduced claustrum activation, and ultimately suppressed anxiety-like behaviors in ACE mice during adulthood. EA treatment alleviated ACE-evoked claustrum activation and anxiety-like behaviors by suppressing claustrum D1RCaMKII.

Conclusion: Our findings identified a novel role of claustrum in ACE-induced anxiety-like behaviors, and put new insight into the D1RCaMKII in the claustrum. The claustrum D1RCaMKII might be a promising pharmacological target, such as EA treatment, to treat drug-induced anxiety-like behaviors.
Files in This Item:
T202307150.pdf Download
DOI
10.7150/thno.83079
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hee Young(김희영) ORCID logo https://orcid.org/0000-0002-2495-9115
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197652
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