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Impact of boost sequence in concurrent chemo-radiotherapy on newly diagnosed IDH-wildtype glioblastoma multiforme
DC Field | Value | Language |
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dc.contributor.author | 강석구 | - |
dc.contributor.author | 문주형 | - |
dc.contributor.author | 윤홍인 | - |
dc.contributor.author | 이준교 | - |
dc.contributor.author | 장종희 | - |
dc.contributor.author | 조재호 | - |
dc.date.accessioned | 2024-01-03T01:11:30Z | - |
dc.date.available | 2024-01-03T01:11:30Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 0167-594X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197488 | - |
dc.description.abstract | Background: The standard of care for glioblastoma multiforme (GBM) is maximal surgical resection followed by conventional fractionated concurrent chemoradiotherapy (CCRT) with a total dose of 60 Gy. However, there is currently no consensus on the optimal boost technique for CCRT in GBM. Methods: We conducted a retrospective review of 398 patients treated with CCRT between 2016 and 2021, using data from two institutional databases. Patients were divided into two groups: those receiving sequential boost (SEB, N = 119) and those receiving simultaneous integrated boost (SIB, N = 279). The primary endpoint was overall survival (OS). To minimize differences between the SIB and SEB groups, we conducted propensity score matching (PSM) analysis. Results: The median follow-up period was 18.6 months. Before PSM, SEB showed better OS compared to SIB (2-year, 55.6% vs. 44.5%, p = 0.014). However, after PSM, there was no significant difference between two groups (2-year, 55.6% vs. 51.5%, p = 0.300). The boost sequence was not associated with inferior OS before and after PSM (all p-values > 0.05). Additionally, the rates of symptomatic pseudo-progression were similar between the two groups (odds ratio: 1.75, p = 0.055). Conclusions: This study found no significant difference in OS between SEB and SIB for GBM patients treated with CCRT. Further research is needed to validate these findings and to determine the optimal boost techniques for this patient population. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | JOURNAL OF NEURO-ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Brain Neoplasms* / drug therapy | - |
dc.subject.MESH | Brain Neoplasms* / therapy | - |
dc.subject.MESH | Chemoradiotherapy / methods | - |
dc.subject.MESH | Glioblastoma* / drug therapy | - |
dc.subject.MESH | Glioblastoma* / therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Impact of boost sequence in concurrent chemo-radiotherapy on newly diagnosed IDH-wildtype glioblastoma multiforme | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학교실) | - |
dc.contributor.googleauthor | Nalee Kim | - |
dc.contributor.googleauthor | Joongyo Lee | - |
dc.contributor.googleauthor | Do-Hyun Nam | - |
dc.contributor.googleauthor | Jung-Il Lee | - |
dc.contributor.googleauthor | Ho Jun Seol | - |
dc.contributor.googleauthor | Doo-Sik Kong | - |
dc.contributor.googleauthor | Jung Won Choi | - |
dc.contributor.googleauthor | Kyuha Chong | - |
dc.contributor.googleauthor | Won Jae Lee | - |
dc.contributor.googleauthor | Jong Hee Chang | - |
dc.contributor.googleauthor | Seok-Gu Kang | - |
dc.contributor.googleauthor | Ju Hyung Moon | - |
dc.contributor.googleauthor | Jaeho Cho | - |
dc.contributor.googleauthor | Do Hoon Lim | - |
dc.contributor.googleauthor | Hong In Yoon | - |
dc.identifier.doi | 10.1007/s11060-023-04465-6 | - |
dc.contributor.localId | A00036 | - |
dc.contributor.localId | A01383 | - |
dc.contributor.localId | A04777 | - |
dc.contributor.localId | A05800 | - |
dc.contributor.localId | A03470 | - |
dc.contributor.localId | A03901 | - |
dc.relation.journalcode | J01629 | - |
dc.identifier.eissn | 1573-7373 | - |
dc.identifier.pmid | 37861921 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s11060-023-04465-6 | - |
dc.subject.keyword | Boost | - |
dc.subject.keyword | Glioblastoma multiforme | - |
dc.subject.keyword | Radiotherapy | - |
dc.contributor.alternativeName | Kang, Seok Gu | - |
dc.contributor.affiliatedAuthor | 강석구 | - |
dc.contributor.affiliatedAuthor | 문주형 | - |
dc.contributor.affiliatedAuthor | 윤홍인 | - |
dc.contributor.affiliatedAuthor | 이준교 | - |
dc.contributor.affiliatedAuthor | 장종희 | - |
dc.contributor.affiliatedAuthor | 조재호 | - |
dc.citation.volume | 162 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 261 | - |
dc.citation.endPage | 268 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEURO-ONCOLOGY, Vol.162(2) : 261-268, 2023-11 | - |
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