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Assessment of Risk Factors for Postoperative Delirium in Older Adults Who Underwent Spinal Surgery and Identifying Associated Biomarkers Using Exosomal Protein
DC Field | Value | Language |
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dc.contributor.author | 구본녀 | - |
dc.contributor.author | 김정민 | - |
dc.contributor.author | 신동아 | - |
dc.contributor.author | 이주희 | - |
dc.contributor.author | 이향규 | - |
dc.contributor.author | 장연수 | - |
dc.date.accessioned | 2024-01-03T01:06:52Z | - |
dc.date.available | 2024-01-03T01:06:52Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 2005-3673 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197459 | - |
dc.description.abstract | Purpose: With an increase in the aging population, the number of patients with degenerative spinal diseases undergoing surgery has risen, as has the incidence of postoperative delirium. This study aimed to investigate the risk factors affecting postoperative delirium in older adults who had undergone spine surgery and to identify the associated biomarkers. Methods: This study is a prospective study. Data of 100 patients aged ≥ 70 years who underwent spinal surgery were analyzed. Demographic data, medical history, clinical characteristics, cognitive function, depression symptoms, functional status, frailty, and nutritional status were investigated to identify the risk factors for delirium. The Confusion Assessment Method, Delirium Rating Scale-R-98, and Nursing Delirium Scale were also used for diagnosing delirium. To discover the biomarkers, urine extracellular vesicles (EVs) were analyzed for tau, ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), neurofilament light, and glial fibrillary acidic protein using digital immunoassay technology. Results: Nine patients were excluded, and data obtained from the remaining 91 were analyzed. Among them, 18 (19.8%) developed delirium. Differences were observed between participants with and without delirium in the contexts of a history of mental disorder and use of benzodiazepines (p = .005 and p = .026, respectively). Tau and UCH-L1-concentrations of urine EVs-were comparatively higher in participants with severe delirium than that in participants without delirium (p = .002 and p = .001, respectively). Conclusion: These findings can assist clinicians in accurately identifying the risk factors before surgery, classifying high-risk patients, and predicting and detecting delirium in older patients. Moreover, urine EV analysis revealed that postoperative delirium following spinal surgery is most likely associated with brain damage. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | Korean, English | - |
dc.publisher | Korean Society of Nursing Science | - |
dc.relation.isPartOf | JOURNAL OF KOREAN ACADEMY OF NURSING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aging | - |
dc.subject.MESH | Biomarkers | - |
dc.subject.MESH | Emergence Delirium* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Assessment of Risk Factors for Postoperative Delirium in Older Adults Who Underwent Spinal Surgery and Identifying Associated Biomarkers Using Exosomal Protein | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Wonhee Baek | - |
dc.contributor.googleauthor | JuHee Lee | - |
dc.contributor.googleauthor | Yeonsoo Jang | - |
dc.contributor.googleauthor | Jeongmin Kim | - |
dc.contributor.googleauthor | Dong Ah Shin | - |
dc.contributor.googleauthor | Hyunki Park | - |
dc.contributor.googleauthor | Bon-Nyeo Koo | - |
dc.contributor.googleauthor | Hyangkyu Lee | - |
dc.identifier.doi | 10.4040/jkan.22146 | - |
dc.contributor.localId | A00193 | - |
dc.contributor.localId | A00884 | - |
dc.contributor.localId | A02092 | - |
dc.contributor.localId | A03172 | - |
dc.contributor.localId | A03282 | - |
dc.contributor.localId | A03450 | - |
dc.relation.journalcode | J04043 | - |
dc.identifier.eissn | 2093-758X | - |
dc.identifier.pmid | 37673813 | - |
dc.identifier.url | https://jkan.or.kr/DOIx.php?id=10.4040/jkan.22146 | - |
dc.subject.keyword | Aging | - |
dc.subject.keyword | Biomarkers | - |
dc.subject.keyword | Delirium | - |
dc.subject.keyword | Extracellular Vesicles | - |
dc.subject.keyword | Postoperative Period | - |
dc.contributor.alternativeName | Ku, Bon Nyo | - |
dc.contributor.affiliatedAuthor | 구본녀 | - |
dc.contributor.affiliatedAuthor | 김정민 | - |
dc.contributor.affiliatedAuthor | 신동아 | - |
dc.contributor.affiliatedAuthor | 이주희 | - |
dc.contributor.affiliatedAuthor | 이향규 | - |
dc.contributor.affiliatedAuthor | 장연수 | - |
dc.citation.volume | 53 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 371 | - |
dc.citation.endPage | 384 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN ACADEMY OF NURSING, Vol.53(4) : 371-384, 2023-08 | - |
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