Cited 0 times in
Three year post heart transplant outcomes of desensitized durable mechanical circulatory support patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이혜선 | - |
dc.date.accessioned | 2024-01-03T01:04:03Z | - |
dc.date.available | 2024-01-03T01:04:03Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 1053-2498 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197454 | - |
dc.description.abstract | Background: The risks and benefits of desensitization therapy (DST) in highly sensitized mechanical circulatory support (MCS) patients are not well known. We investigated 3 year post-transplant outcomes of desensitized durable MCS patients. Methods: Among 689 consecutively enrolled heart transplantation recipients between 2010 and 2016, we categorized them into Group A (desensitized MCS patients, n = 21), Group B (desensitized non-MCS patients, n = 28) and Group C (all nondesensitized patients, n = 640). Post-transplant outcomes included the incidence of primary graft dysfunction, 3-year survival, freedom from cardiac allograft vasculopathy, nonfatal major adverse cardiac events, any treated rejection, acute cellular rejection, antibody mediated rejection (AMR) and infectious complications. Results: The types of DST in Groups A and B were similar and included combinations of rituximab/intravenous immunoglobulin and plasmapheresis/bortezomib. Group A, compared with Group B, showed significantly higher pre-DST panel reactive antibody (PRA) (92.2 ± 9.8 vs. 83.3 ± 15.6, P = 0.007) and higher PRA reduction after DST (-22.2 ± 26.9 vs. -6.3 ± 7.5, P = 0.015). Groups A and C showed comparable primary graft dysfunction, 3-year survival, freedom from cardiac allograft vasculopathy, nonfatal major adverse cardiac events, any treated rejection, acute cellular rejection, and AMR. Although statistically not significant, Group A showed numerically higher 3-year freedom from AMR than Group B. Infectious complications were similar in both Groups A and B. Conclusions: DST for MCS patients showed significant PRA reduction, resulting in an expansion of the donor pool. The post-transplant outcome of desensitized MCS patients showed comparable clinical outcomes to non-desensitized control patients in the same study period, revealing the safety and efficacy of DST. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | JOURNAL OF HEART AND LUNG TRANSPLANTATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Antibodies | - |
dc.subject.MESH | Graft Rejection | - |
dc.subject.MESH | Graft Survival | - |
dc.subject.MESH | Heart Transplantation* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Transplantation* / adverse effects | - |
dc.subject.MESH | Primary Graft Dysfunction* / etiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Three year post heart transplant outcomes of desensitized durable mechanical circulatory support patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Jong-Chan Youn | - |
dc.contributor.googleauthor | Darae Kim | - |
dc.contributor.googleauthor | Mi-Hyang Jung | - |
dc.contributor.googleauthor | Jin-Jin Kim | - |
dc.contributor.googleauthor | In-Cheol Kim | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Jin-Oh Choi | - |
dc.contributor.googleauthor | Eun-Seok Jeon | - |
dc.contributor.googleauthor | Keith Nishihara | - |
dc.contributor.googleauthor | Osamu Seguchi | - |
dc.contributor.googleauthor | Evan P Kransdorf | - |
dc.contributor.googleauthor | David H Chang | - |
dc.contributor.googleauthor | Michelle M Kittleson | - |
dc.contributor.googleauthor | Jignesh K Patel | - |
dc.contributor.googleauthor | Robert M Cole | - |
dc.contributor.googleauthor | Jaime D Moriguchi | - |
dc.contributor.googleauthor | Danny Ramzy | - |
dc.contributor.googleauthor | Fardad Esmailian | - |
dc.contributor.googleauthor | Jon A Kobashigawa | - |
dc.identifier.doi | 10.1016/j.healun.2023.05.001 | - |
dc.contributor.localId | A03312 | - |
dc.relation.journalcode | J01436 | - |
dc.identifier.eissn | 1557-3117 | - |
dc.identifier.pmid | 37150473 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S105324982301851X | - |
dc.subject.keyword | desensitization therapy | - |
dc.subject.keyword | heart transplantation | - |
dc.subject.keyword | infection | - |
dc.subject.keyword | mechanical circulatory support | - |
dc.subject.keyword | prognosis | - |
dc.contributor.alternativeName | Lee, Hye Sun | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.citation.volume | 42 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1408 | - |
dc.citation.endPage | 1414 | - |
dc.identifier.bibliographicCitation | JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol.42(10) : 1408-1414, 2023-10 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.