48 83

Cited 1 times in

Discovery of New Anti-Cancer Agents against Patient-Derived Sorafenib-Resistant Papillary Thyroid Cancer

Authors
 Yuna Kim  ;  Hyeok Jun Yun  ;  Kyung Hwa Choi  ;  Chan Wung Kim  ;  Jae Ha Lee  ;  Raymond Weicker  ;  Seok-Mo Kim  ;  Ki Cheong Park 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.24(22) : 16413, 2023-11 
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN
 1661-6596 
Issue Date
2023-11
MeSH
Animals ; Antineoplastic Agents* / pharmacology ; Antineoplastic Agents* / therapeutic use ; Cell Line, Tumor ; Disease Models, Animal ; Humans ; Sorafenib / pharmacology ; Sorafenib / therapeutic use ; Thyroid Cancer, Papillary / drug therapy ; Thyroid Neoplasms* / drug therapy ; Thyroid Neoplasms* / pathology
Keywords
anti-cancer drug resistant papillary thyroid cancer ; patient-derived papillary thyroid cancer ; sorafenib
Abstract
Thyroid cancer is the most well-known type of endocrine cancer that is easily treatable and can be completely cured in most cases. Nonetheless, anti-cancer drug-resistant metastasis or recurrence may occur and lead to the failure of cancer therapy, which eventually leads to the death of a patient with cancer. This study aimed to detect novel thyroid cancer target candidates based on validating and identifying one of many anti-cancer drug-resistant targets in patient-derived sorafenib-resistant papillary thyroid cancer (PTC). We focused on targeting the sarco/endoplasmic reticulum calcium ATPase (SERCA) in patient-derived sorafenib-resistant PTC cells compared with patient-derived sorafenib-sensitive PTC cells. We discovered novel SERCA inhibitors (candidates 33 and 36) by virtual screening. These candidates are novel SERCA inhibitors that lead to remarkable tumor shrinkage in a xenograft tumor model of sorafenib-resistant patient-derived PTC cells. These results are clinically valuable for the progression of novel combinatorial strategies that facultatively and efficiently target extremely malignant cancer cells, such as anti-cancer drug-resistant PTC cells.
Files in This Item:
T202306962.pdf Download
DOI
10.3390/ijms242216413
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seok Mo(김석모) ORCID logo https://orcid.org/0000-0001-8070-0573
Kim, Yuna(김윤아)
Park, Ki Cheong(박기청) ORCID logo https://orcid.org/0000-0002-3435-3985
Yun, Hyeok Jun(윤혁준) ORCID logo https://orcid.org/0000-0001-6004-0782
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197392
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links