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Roles of Protein Post-Translational Modifications During Adipocyte Senescence

Authors
 Min-Seon Hwang  ;  Jingyeong Park  ;  Yunha Ham  ;  In Hye Lee  ;  Kyung-Hee Chun 
Citation
 INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, Vol.19(16) : 5245-5256, 2023-10 
Journal Title
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Issue Date
2023-10
MeSH
Adipocytes, Brown* / metabolism ; Adipogenesis / genetics ; Adipose Tissue, Brown* / metabolism ; Cell Cycle Checkpoints ; Protein Processing, Post-Translational
Keywords
Adipocyte ; Metabolic disease ; Metabolic homeostasis ; Post-translational modification ; Senescence
Abstract
Adipocytes are adipose tissues that supply energy to the body through lipids. The two main types of adipocytes comprise white adipocytes (WAT) that store energy, and brown adipocytes (BAT), which generate heat by burning stored fat (thermogenesis). Emerging evidence indicates that dysregulated adipocyte senescence may disrupt metabolic homeostasis, leading to various diseases and aging. Adipocytes undergo senescence via irreversible cell-cycle arrest in response to DNA damage, oxidative stress, telomere dysfunction, or adipocyte over-expansion upon chronic lipid accumulation. The amount of detectable BAT decreases with age. Activation of cell cycle regulators and dysregulation of adipogenesis-regulating factors may constitute a molecular mechanism that accelerates adipocyte senescence. To better understand the regulation of adipocyte senescence, the effects of post-translational modifications (PTMs), is essential for clarifying the activity and stability of these proteins. PTMs are covalent enzymatic protein modifications introduced following protein biosynthesis, such as phosphorylation, acetylation, ubiquitination, or glycosylation. Determining the contribution of PTMs to adipocyte senescence may identify new therapeutic targets for the regulation of adipocyte senescence. In this review, we discuss a conceptual case in which PTMs regulate adipocyte senescence and explain the mechanisms underlying protein regulation, which may lead to the development of effective strategies to combat metabolic diseases.
Files in This Item:
T202307018.pdf Download
DOI
10.7150/ijbs.86404
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Chun, Kyung Hee(전경희) ORCID logo https://orcid.org/0000-0002-9867-7321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197385
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