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Is the cingulate island sign a marker for early dementia conversion in Parkinson's disease?
DC Field | Value | Language |
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dc.contributor.author | 김윤중 | - |
dc.contributor.author | 손영호 | - |
dc.contributor.author | 이필휴 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 정석종 | - |
dc.contributor.author | 박찬욱 | - |
dc.date.accessioned | 2024-01-03T00:37:54Z | - |
dc.date.available | 2024-01-03T00:37:54Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 1351-5101 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197323 | - |
dc.description.abstract | Background: To investigate whether the cingulate island sign (CIS) ratio (i.e., the ratio of regional uptake in the posterior cingulate cortex relative to the precuneus and cuneus on cerebral perfusion scans) is associated with early dementia conversion in Parkinson's disease (PD). Methods: We enrolled 226 patients with newly diagnosed PD and 48 healthy controls who underwent dual-phase 18 F-FP-CIT PET scans. Patients with PD were classified into three groups according to the CIS ratio on early-phase 18 F-FP-CIT PET images: a PD group with CIS or high CIS ratios (PD-CIS; n = 96), a PD group with inverse CIS or low CIS ratios (PD-iCIS; n = 40), and a PD group consisting of the remaining patients with normal CIS ratios (PD-nCIS; n = 90). We compared the risk of dementia conversion within a 5-year time point between the groups. Results: There were no significant differences in age, sex, education, or baseline cognitive function between the PD groups. The PD-CIS group had higher Unified Parkinson's Disease Rating Scale (UPDRS) motor scores and more severely decreased dopamine transporter availability in the putamen. The PD-iCIS group had a smaller hippocampal volume compared with the other groups. The risk of dementia conversion in the PD-CIS group did not differ from that in the PD-iCIS and PD-nCIS groups. Meanwhile, the PD-iCIS group had a higher risk of dementia conversion than the PD-nCIS group. Conclusion: The results of this study suggest that inverse CIS, rather than CIS, is relevant to early dementia conversion in patients with PD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Dementia* / diagnostic imaging | - |
dc.subject.MESH | Dementia* / etiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Parkinson Disease* / complications | - |
dc.subject.MESH | Parkinson Disease* / diagnostic imaging | - |
dc.subject.MESH | Positron-Emission Tomography | - |
dc.subject.MESH | Tropanes | - |
dc.title | Is the cingulate island sign a marker for early dementia conversion in Parkinson's disease? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Seok Jong Chung | - |
dc.contributor.googleauthor | Su Hong Kim | - |
dc.contributor.googleauthor | Chan Wook Park | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Yun Joong Kim | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.contributor.googleauthor | Yong Jeong | - |
dc.contributor.googleauthor | Young H Sohn | - |
dc.identifier.doi | 10.1111/ene.16007 | - |
dc.contributor.localId | A00796 | - |
dc.contributor.localId | A01982 | - |
dc.contributor.localId | A03270 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A04666 | - |
dc.relation.journalcode | J00830 | - |
dc.identifier.eissn | 1468-1331 | - |
dc.identifier.pmid | 37505994 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/ene.16007 | - |
dc.subject.keyword | 18F-FP-CIT PET | - |
dc.subject.keyword | Parkinson's disease | - |
dc.subject.keyword | cerebral perfusion | - |
dc.subject.keyword | cingulate island sign | - |
dc.subject.keyword | dementia | - |
dc.contributor.alternativeName | Kim, Yun Joong | - |
dc.contributor.affiliatedAuthor | 김윤중 | - |
dc.contributor.affiliatedAuthor | 손영호 | - |
dc.contributor.affiliatedAuthor | 이필휴 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.contributor.affiliatedAuthor | 정석종 | - |
dc.citation.volume | 30 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 3732 | - |
dc.citation.endPage | 3740 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF NEUROLOGY, Vol.30(12) : 3732-3740, 2023-12 | - |
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