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Prior antibiotic administration disrupts anti-PD-1 responses in advanced gastric cancer by altering the gut microbiome and systemic immune response

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dc.contributor.author김지형-
dc.contributor.author김현기-
dc.contributor.author김효송-
dc.contributor.author라선영-
dc.contributor.author신수진-
dc.contributor.author안진영-
dc.contributor.author이서영-
dc.contributor.author이충근-
dc.contributor.author정민규-
dc.contributor.author정현철-
dc.contributor.author정희철-
dc.contributor.author김창곤-
dc.contributor.author홍문기-
dc.contributor.author이지현-
dc.contributor.author윤언정-
dc.contributor.author김현욱-
dc.date.accessioned2024-01-03T00:29:05Z-
dc.date.available2024-01-03T00:29:05Z-
dc.date.issued2023-11-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/197272-
dc.description.abstractEvidence on whether prior antibiotic (pATB) administration modulates outcomes of programmed cell death protein-1 (PD-1) inhibitors in advanced gastric cancer (AGC) is scarce. In this study, we find that pATB administration is consistently associated with poor progression-free survival (PFS) and overall survival (OS) in multiple cohorts consisting of patients with AGC treated with PD-1 inhibitors. In contrast, pATB does not affect outcomes among patients treated with irinotecan. Multivariable analysis of the overall patients treated with PD-1 inhibitors confirms that pATB administration independently predicts worse PFS and OS. Administration of pATBs is associated with diminished gut microbiome diversity, reduced abundance of Lactobacillus gasseri, and disproportional enrichment of circulating exhaustive CD8+ T cells, all of which are associated with worse outcomes. Considering the inferior treatment response and poor survival outcomes by pATB administration followed by PD-1 blockade, ATBs should be prescribed with caution in patients with AGC who are planning to receive PD-1 inhibitors.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherCell Press-
dc.relation.isPartOfCELL REPORTS MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnti-Bacterial Agents-
dc.subject.MESHCD8-Positive T-Lymphocytes-
dc.subject.MESHGastrointestinal Microbiome*-
dc.subject.MESHHumans-
dc.subject.MESHImmune Checkpoint Inhibitors / therapeutic use-
dc.subject.MESHProgrammed Cell Death 1 Receptor-
dc.subject.MESHStomach Neoplasms* / drug therapy-
dc.titlePrior antibiotic administration disrupts anti-PD-1 responses in advanced gastric cancer by altering the gut microbiome and systemic immune response-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorChang Gon Kim-
dc.contributor.googleauthorJune-Young Koh-
dc.contributor.googleauthorSu-Jin Shin-
dc.contributor.googleauthorJi-Hee Shin-
dc.contributor.googleauthorMoonki Hong-
dc.contributor.googleauthorHyun Cheol Chung-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorHyo Song Kim-
dc.contributor.googleauthorChoong-Kun Lee-
dc.contributor.googleauthorJi Hyun Lee-
dc.contributor.googleauthorYejeong Han-
dc.contributor.googleauthorHyoyong Kim-
dc.contributor.googleauthorXiumei Che-
dc.contributor.googleauthorUn-Jung Yun-
dc.contributor.googleauthorHyunki Kim-
dc.contributor.googleauthorJee Hung Kim-
dc.contributor.googleauthorSeo Young Lee-
dc.contributor.googleauthorSu Kyoung Park-
dc.contributor.googleauthorSejung Park-
dc.contributor.googleauthorHyunwook Kim-
dc.contributor.googleauthorJin Young Ahn-
dc.contributor.googleauthorHei-Cheul Jeung-
dc.contributor.googleauthorJeong Seok Lee-
dc.contributor.googleauthorYoung-Do Nam-
dc.contributor.googleauthorMinkyu Jung-
dc.identifier.doi10.1016/j.xcrm.2023.101251-
dc.contributor.localIdA00999-
dc.contributor.localIdA01108-
dc.contributor.localIdA01202-
dc.contributor.localIdA01316-
dc.contributor.localIdA04596-
dc.contributor.localIdA02267-
dc.contributor.localIdA06098-
dc.contributor.localIdA03259-
dc.contributor.localIdA03606-
dc.contributor.localIdA03773-
dc.contributor.localIdA03794-
dc.relation.journalcodeJ04379-
dc.identifier.eissn2666-3791-
dc.identifier.pmid37890486-
dc.subject.keywordPD-1 inhibitor-
dc.subject.keywordadvanced gastric cancer-
dc.subject.keywordantibiotics-
dc.subject.keywordchemotherapy-
dc.subject.keywordgut microbiome-
dc.subject.keywordsystemic immune response-
dc.contributor.alternativeNameKim, Jee Hung-
dc.contributor.affiliatedAuthor김지형-
dc.contributor.affiliatedAuthor김현기-
dc.contributor.affiliatedAuthor김효송-
dc.contributor.affiliatedAuthor라선영-
dc.contributor.affiliatedAuthor신수진-
dc.contributor.affiliatedAuthor안진영-
dc.contributor.affiliatedAuthor이서영-
dc.contributor.affiliatedAuthor이충근-
dc.contributor.affiliatedAuthor정민규-
dc.contributor.affiliatedAuthor정현철-
dc.contributor.affiliatedAuthor정희철-
dc.citation.volume4-
dc.citation.number11-
dc.citation.startPage101251-
dc.identifier.bibliographicCitationCELL REPORTS MEDICINE, Vol.4(11) : 101251, 2023-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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