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Bickerstaff's brainstem encephalitis: a rare case of neurologic complication in Ulcerative Colitis

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dc.contributor.author김한결-
dc.contributor.author조한나-
dc.contributor.author한진우-
dc.date.accessioned2024-01-03T00:20:44Z-
dc.date.available2024-01-03T00:20:44Z-
dc.date.issued2023-10-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/197238-
dc.description.abstractBickerstaff's brainstem encephalitis is a rare autoimmune disorder that presents with ataxia, ophthalmoplegia, disturbance of consciousness and quadriplegia. A 45-year-old man with a history of ulcerative colitis (UC) taking mesalazine (5-aminosalicylic acid) visited the emergency room presenting with ataxia, ophthalmoplegia and a progressively worsening cognitive impairment. Cerebrospinal fluid analysis showed mild elevation in protein and white blood cell count and increased intracranial pressure. Anti-GQ1b autoantibodies were found positive in the patient's serum and contrast-enhanced brain magnetic resonance imaging showed diffuse leptomeningeal enhancement and pontine lesions. Based on these findings and the patient's clinical course and history, he was diagnosed with Bickerstaff's brainstem encephalitis. Mesalazine was discontinued and high-dose steroid pulse therapy was started, followed by intravenous immunoglobulin, which resulted in gradual improvement of the neurologic symptoms. When an ulcerative colitis patient presents with progressive cognitive impairment, quadriplegia and disturbance of consciousness and gait, Bickerstaff brainstem encephalitis should be considered in the differential diagnosis and prompt immunotherapy may lead to favorable prognosis.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfBMC NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAtaxia / complications-
dc.subject.MESHAutoimmune Diseases of the Nervous System*-
dc.subject.MESHBrain Stem / diagnostic imaging-
dc.subject.MESHBrain Stem / pathology-
dc.subject.MESHColitis, Ulcerative* / complications-
dc.subject.MESHColitis, Ulcerative* / pathology-
dc.subject.MESHEncephalitis* / complications-
dc.subject.MESHEncephalitis* / diagnosis-
dc.subject.MESHGangliosides-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMesalamine-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOphthalmoplegia*-
dc.subject.MESHQuadriplegia-
dc.titleBickerstaff's brainstem encephalitis: a rare case of neurologic complication in Ulcerative Colitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorHaram Joo-
dc.contributor.googleauthorChung Seok Lee-
dc.contributor.googleauthorSangwon Joe-
dc.contributor.googleauthorJinu Han-
dc.contributor.googleauthorHan-Kyeol Kim-
dc.contributor.googleauthorHanna Cho-
dc.identifier.doi10.1186/s12883-023-03430-0-
dc.contributor.localIdA05235-
dc.contributor.localIdA03920-
dc.contributor.localIdA04329-
dc.relation.journalcodeJ00368-
dc.identifier.eissn1471-2377-
dc.identifier.pmid37884876-
dc.subject.keywordAutoimmune encephalitis-
dc.subject.keywordBickerstaff’s brainstem encephalitis-
dc.subject.keywordEncephalitis-
dc.subject.keywordInflammatory bowel disorder-
dc.subject.keywordMesalazine-
dc.subject.keywordUlcerative Colitis-
dc.contributor.alternativeNameKim, Han kyeol-
dc.contributor.affiliatedAuthor김한결-
dc.contributor.affiliatedAuthor조한나-
dc.contributor.affiliatedAuthor한진우-
dc.citation.volume23-
dc.citation.number1-
dc.citation.startPage386-
dc.identifier.bibliographicCitationBMC NEUROLOGY, Vol.23(1) : 386, 2023-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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