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Implication of TIPE2 Expression on the Malignant Transformation of Oral Leukoplakia

Authors
 Haiyue Chen  ;  Meiling Pei  ;  Seung Woo Shin  ;  Sook Moon  ;  Woong Nam  ;  Zhenlong Zheng 
Citation
 ANTICANCER RESEARCH, Vol.43(11) : 4937-4946, 2023-11 
Journal Title
ANTICANCER RESEARCH
ISSN
 0250-7005 
Issue Date
2023-11
MeSH
Humans ; Hyperplasia ; Keratinocytes* ; Leukoplakia, Oral* / genetics ; Multivariate Analysis ; Risk Factors
Keywords
Oral leukoplakia ; TIPE2 ; biomarker ; dormancy ; malignant transformation
Abstract
Background/aim: Identification of biomarkers involved in the malignant transformation of oral leukoplakia (OL) is required for the early diagnosis and management of patients with OL. This study aimed to evaluate the functions of tumor necrosis factor-alpha-induced protein 8-like 2 (TIPE2) expression in the malignant transformation of OL.

Materials and methods: The expression levels of TIPE2 and dormant cell markers phospho-ERK and phospho-p38 in a cohort containing 103 surgical specimens from patients with OL were evaluated using immunohistochemistry. The influence of TIPE2 expression on the biological behavior of the immortalized human oral keratinocyte (IHOK) line was investigated in vitro.

Results: Increased TIPE2 expression was detected in 40 (38.8%) patients with OL. In a multivariate analysis using clinicopathological variables and TIPE2 expression as cofactors, the presence of dysplasia (p=0.003) and TIPE2 abundance (p=0.019) were identified as independent risk factors for the malignant transformation of OL. Moreover, the in vitro analysis revealed that TIPE2 knockdown can promote the proliferating ability of IHOK; however, the number of apoptotic cells also increased after TIPE2 knockdown in IHOK. Furthermore, TIPE2 expression was significantly associated with phospho-p38 expression, a dormant cell marker, in our cohort (p=0.047).

Conclusion: TIPE2 expression may contribute to the malignant transformation of OL, and its function may be related to cellular dormancy in OL pathogenesis.
Full Text
https://ar.iiarjournals.org/content/43/11/4937
DOI
10.21873/anticanres.16691
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Nam, Woong(남웅) ORCID logo https://orcid.org/0000-0003-0146-3624
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197209
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