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Prostaglandin F2α analogue, bimatoprost ameliorates colistin-induced nephrotoxicity
DC Field | Value | Language |
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dc.contributor.author | 김혜연 | - |
dc.contributor.author | 지헌영 | - |
dc.date.accessioned | 2023-11-28T03:31:52Z | - |
dc.date.available | 2023-11-28T03:31:52Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 0753-3322 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196840 | - |
dc.description.abstract | Colistin (polymyxin E) is an antibiotic that is effective against multidrug-resistant gram-negative bacteria. However, the high incidence of nephrotoxicity caused by colistin limits its clinical use. To identify compounds that might ameliorate colistin-induced nephrotoxicity, we obtained 1707 compounds from the Korea Chemical Bank and used a high-content screening (HCS) imaging-based assay. In this way, we found that bimatoprost (one of prostaglandin F2α analogue) ameliorated colistin-induced nephrotoxicity. To further assess the effects of bimatoprost on colistin-induced nephrotoxicity, we used in vitro and in vivo models. In cultured human proximal tubular cells (HK-2), colistin induced dose-dependent cytotoxicity. The number of terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)-positive cells, indicative of apoptosis, was higher in colistin-treated cells, but this effect of colistin was ameliorated by cotreatment with bimatoprost. The generation of reactive oxygen species, assessed using 2,7-dichlorodihydrofluorescein diacetate, was less marked in cells treated with both colistin and bimatoprost than in those treated with colistin alone. Female C57BL/6 mice (n = 10 per group) that were intraperitoneally injected with colistin (10 mg/kg/12 hr) for 14 days showed high blood urea nitrogen and serum creatinine concentrations that were reduced by the coadministration of bimatoprost (0.5 mg/kg/12 hr). In addition, kidney injury molecule-1 (KIM1) and Neutrophil gelatinase-associated lipocalin (NGAL) expression also reduced by bimatoprost administration. Further investigation in tubuloid and kidney organoids also showed that bimatoprost attenuated the nephrotoxicity by colistin, showing dose-dependent reducing effect of KIM1 expression. In this study, we have identified bimatoprost, prostaglandin F2α analogue as a drug that ameliorates colistin-induced nephrotoxicity. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, French | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | BIOMEDICINE & PHARMACOTHERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Bacterial Agents / toxicity | - |
dc.subject.MESH | Bimatoprost / metabolism | - |
dc.subject.MESH | Bimatoprost / pharmacology | - |
dc.subject.MESH | Colistin* / pharmacology | - |
dc.subject.MESH | Dinoprost* / metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Prostaglandins / metabolism | - |
dc.title | Prostaglandin F2α analogue, bimatoprost ameliorates colistin-induced nephrotoxicity | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | Lina Joo | - |
dc.contributor.googleauthor | Hye Yun Jeong | - |
dc.contributor.googleauthor | Dong Hyuck Bae | - |
dc.contributor.googleauthor | Joo Hyun Jee | - |
dc.contributor.googleauthor | Woo Hee Choi | - |
dc.contributor.googleauthor | Hye-Youn Kim | - |
dc.contributor.googleauthor | Sejoong Kim | - |
dc.contributor.googleauthor | Dong-Ho Yang | - |
dc.contributor.googleauthor | Heon Yung Gee | - |
dc.contributor.googleauthor | SeongGyeong Jeon | - |
dc.contributor.googleauthor | Yun-Gil Roh | - |
dc.contributor.googleauthor | Jongman Yoo | - |
dc.identifier.doi | 10.1016/j.biopha.2023.115446 | - |
dc.contributor.localId | A05467 | - |
dc.contributor.localId | A03971 | - |
dc.relation.journalcode | J00322 | - |
dc.identifier.eissn | 1950-6007 | - |
dc.identifier.pmid | 37918255 | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Bimatoprost | - |
dc.subject.keyword | Colistin | - |
dc.subject.keyword | Drug repurposing | - |
dc.subject.keyword | Nephrotoxicity | - |
dc.subject.keyword | Oxidative stress | - |
dc.contributor.alternativeName | Kim, Hye-Youn | - |
dc.contributor.affiliatedAuthor | 김혜연 | - |
dc.contributor.affiliatedAuthor | 지헌영 | - |
dc.citation.volume | 168 | - |
dc.citation.startPage | 115446 | - |
dc.identifier.bibliographicCitation | BIOMEDICINE & PHARMACOTHERAPY, Vol.168 : 115446, 2023-12 | - |
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