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Prediction of Prognosis in Pancreatic Cancer According to Methionyl-tRNA Synthetase 1 Expression as Determined by Immunohistochemical Staining

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dc.contributor.author남지해-
dc.contributor.author박준성-
dc.contributor.author이동기-
dc.contributor.author이혜선-
dc.contributor.author장성일-
dc.contributor.author조재희-
dc.contributor.author이시영-
dc.contributor.author도민영-
dc.date.accessioned2023-11-28T03:29:51Z-
dc.date.available2023-11-28T03:29:51Z-
dc.date.issued2023-11-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/196828-
dc.description.abstractThe serum level of CA 19-9 is a prognostic marker for pancreatic ductal adenocarcinoma (PDAC). We evaluated the ability of the expression level of methionyl-tRNA synthetase 1 (MARS1)—which facilitates cancer growth by modulating protein synthesis and the cell cycle—to predict the prognosis of PDAC. Immunohistochemical (IHC) staining was performed on pancreatic specimens obtained from patients with PDAC who were undergoing surgery. High MARS1 expression was defined as equal to, or greater than, that in normal acinar cells. Low MARS1 expression was defined as weaker than in normal acinar cells, and stronger than in the pancreatic duct epithelium. Univariate and multivariate analyses were performed on other factors related to prognosis. Among 137 PDAC patients, no significant differences in baseline characteristics were found between those with high (n = 82) and low (n = 55) MARS1 expression. The median overall survival time of patients with high MARS1 expression was shorter than that of those with low expression (15.2 versus 17.2 months, log-rank test p = 0.044). The median disease-free survival (DFS) was not significantly different between the two groups. However, the DFS was shorter in patients with high than in those with low MARS1 expression (8.9 versus 11.2 months, log-rank test p = 0.067). In a multivariate analysis, lymph node metastasis and high MARS1 expression were associated with a poor prognosis of PDAC. Elevated MARS1 expression detected by IHC staining is associated with a poor prognosis of PDAC, suggesting that MARS1 has potential as a prognostic marker.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfCANCERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePrediction of Prognosis in Pancreatic Cancer According to Methionyl-tRNA Synthetase 1 Expression as Determined by Immunohistochemical Staining-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorSung Ill Jang-
dc.contributor.googleauthorJi Hae Nahm-
dc.contributor.googleauthorSee Young Lee-
dc.contributor.googleauthorJae Hee Cho-
dc.contributor.googleauthorMin-Young Do-
dc.contributor.googleauthorJoon Seong Park-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorJuyeon Yang-
dc.contributor.googleauthorJiwon Kong-
dc.contributor.googleauthorSeunghwan Jung-
dc.contributor.googleauthorSunghoon Kim-
dc.contributor.googleauthorDong Ki Lee-
dc.identifier.doi10.3390/cancers15225413-
dc.contributor.localIdA05120-
dc.contributor.localIdA01672-
dc.contributor.localIdA02723-
dc.contributor.localIdA03312-
dc.contributor.localIdA03441-
dc.contributor.localIdA03902-
dc.relation.journalcodeJ03449-
dc.identifier.eissn2072-6694-
dc.subject.keywordmethionyl-tRNA synthetase 1-
dc.subject.keywordpancreatic ductal adenocarcinoma-
dc.subject.keywordprognostic marker-
dc.contributor.alternativeNameNahm, Ji Hae-
dc.contributor.affiliatedAuthor남지해-
dc.contributor.affiliatedAuthor박준성-
dc.contributor.affiliatedAuthor이동기-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor장성일-
dc.contributor.affiliatedAuthor조재희-
dc.citation.volume15-
dc.citation.number22-
dc.citation.startPage5413-
dc.identifier.bibliographicCitationCANCERS, Vol.15(22) : 5413, 2023-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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