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Postoperative Bloodstream Infection Is Associated with Early Vascular Complications in Pediatric Liver Transplant Recipients with Biliary Atresia

Authors
 Ho Jong Jeon  ;  Ji-Man Kang  ;  Hong Koh  ;  Myoung Soo Kim  ;  Kyong Ihn 
Citation
 JOURNAL OF CLINICAL MEDICINE, Vol.12(21) : 6760, 2023-10 
Journal Title
JOURNAL OF CLINICAL MEDICINE
Issue Date
2023-10
Keywords
bacteremia ; biliary atresia ; bloodstream infection ; pediatric liver transplant ; vascular complication
Abstract
Bloodstream infection (BSI) after pediatric liver transplantation (PLT) is a common and severe complication that affects patient survival. Children with biliary atresia (BA) are at an increased risk for clinically significant infections. This study evaluated the impact of post-PLT BSI on clinical outcomes in children with BA. A total of 67 patients with BA aged <18 years who underwent PLT between April 2006 and September 2020 were analyzed and divided into two groups according to the occurrence of post-PLT BSI within 1 month (BSI vs. no BSI = 13 [19.4%] vs. 54 [80.6%]). The BSI group was significantly younger at the time of PLT and had a higher frequency of BSI at the time of PLT than the no BSI group. Early vascular complications within 3 months and reoperations were significantly more frequent in the BSI group. Univariate and multivariate analyses revealed that bacteremia within 1 month of PLT and graft-to-recipient weight ratio >4% were significantly associated with vascular complications. In conclusion, BSI after PLT is associated with increased vascular complications and reoperations. Proper control of bacterial infections and early liver transplantation before uncontrolled BSI may reduce vascular complications and unexpected reoperations in children with BA.
Files in This Item:
T202306266.pdf Download
DOI
10.3390/jcm12216760
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Ji-Man(강지만) ORCID logo https://orcid.org/0000-0002-0678-4964
Koh, Hong(고홍) ORCID logo https://orcid.org/0000-0002-3660-7483
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Ihn, Kyong(인경) ORCID logo https://orcid.org/0000-0002-6161-0078
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/196765
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