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Randomised controlled trial of a behavioural intervention to reduce exposure to PM2.5 in patients with COPD

 Jieun Kang  ;  Hwan-Cheol Kim  ;  Youngwon Jang  ;  Jung Bok Lee  ;  Jae Seung Lee  ;  Yeon-Mok Oh  ;  Hyun Woo Ji  ;  Ji Ye Jung  ;  Sei Won Lee 
 ENVIRONMENT INTERNATIONAL, Vol.181 : 108286, 2023-11 
Journal Title
Issue Date
Humans ; Pulmonary Disease, Chronic Obstructive* / therapy ; Quality of Life*
Air pollution ; Behavioural intervention ; Chronic obstructive pulmonary disease ; Particulate matter ; Quality of life
Background: Fine particulate matter (PM2.5) is a well-known risk factor for worse outcomes of chronic obstructive pulmonary disease (COPD). However, evidence-based guidance on effective personal behavioural strategies to minimise the effects of PM2.5 is limited. This study aimed to assess the effectiveness of a behavioural intervention in reducing PM2.5 exposure and improving clinical outcomes in patients with COPD.

Materials and methods: Participants were 1:1 randomised, and the intervention group received a behavioural intervention consisting of five activities, while the control group received usual care. The participants were followed up for 9 months. The primary outcomes were differences in the score of St. George's Respiratory Questionnaire for patients with COPD (SGRQ-C) and COPD assessment test (CAT) from baseline.

Results: A total of 106 participants were enrolled and 102 completed the study. At the end of the study, the intervention group showed significant improvements in the primary outcomes compared to the control group, with a group difference of -5.9 in the reduction of total SGRQ-C (-3.4 vs. 2.5; p = 0.049) and -3.8 in the CAT score (-1.2 vs. 2.7; p = 0.001). Participants with good adherence to the intervention demonstrated a greater extent of improvement in CAT score and lower PM2.5 levels compared to those who had poor adherence or were in the control group. Regular checking of air quality forecasts was significantly associated with a reduction in CAT scores among all the intervention activities.

Conclusion: Individual-level behavioural interventions can be an effective strategy for mitigating the health hazards associated with PM2.5.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jung, Ji Ye(정지예) ORCID logo https://orcid.org/0000-0003-1589-4142
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