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Neuropsychological Comparison of Patients With Alzheimer's Disease and Dementia With Lewy Bodies
DC Field | Value | Language |
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dc.contributor.author | 강성우 | - |
dc.contributor.author | 윤소훈 | - |
dc.contributor.author | 나한규 | - |
dc.contributor.author | 이영건 | - |
dc.contributor.author | 전세운 | - |
dc.contributor.author | 백경원 | - |
dc.contributor.author | 손영호 | - |
dc.contributor.author | 예병석 | - |
dc.date.accessioned | 2023-11-20T06:44:13Z | - |
dc.date.available | 2023-11-20T06:44:13Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 1738-6586 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196658 | - |
dc.description.abstract | Background and purpose: This study aimed to determine the neuropsychological differences between patients with early-stage Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) with a Clinical Dementia Rating (CDR) score of ≤1. Methods: We examined 168 patients with AD (126 with CDR score=0.5, 42 with CDR score=1) and 169 patients with DLB (104 with CDR score=0.5, 65 with CDR score=1) whose diagnoses were supported by 18F-flobetaben positron-emission tomography (PET) and 18F-N-(3-fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane PET. Neuropsychological test scores were compared after controlling for age, sex, and education duration. Using a cutoff motor score on the Unified Parkinson's Disease Rating Scale of 20, patients with AD were further divided into AD with parkinsonism (ADP+, n=86) and AD without parkinsonism (ADP-, n=82). Results: At CDR scores of both 0.5 and 1, the DLB group had lower scores on the attention (digit-span forward at CDR score=0.5 and backward at CDR score=1), visuospatial, and executive (color reading Stroop test at CDR score=0.5 and phonemic fluency test, Stroop tests, and digit symbol coding at CDR score=1) tests than the AD group, but higher scores on the memory tests. The ADP- and ADP+ subgroups had comparable scores on most neuropsychological tests, but the ADP+ subgroup had lower scores on the color reading Stroop test. Conclusions: Patients with DLB had worse attention, visuospatial, and executive functions but better memory function than patients with AD. Parkinsonism was not uncommon in the patients with AD and could be related to attention and executive dysfunction. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Neurological Association | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Neuropsychological Comparison of Patients With Alzheimer's Disease and Dementia With Lewy Bodies | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Sungwoo Kang | - |
dc.contributor.googleauthor | So Hoon Yoon | - |
dc.contributor.googleauthor | Han Kyu Na | - |
dc.contributor.googleauthor | Young-Gun Lee | - |
dc.contributor.googleauthor | Seun Jeon | - |
dc.contributor.googleauthor | Kyoungwon Baik | - |
dc.contributor.googleauthor | Young H Sohn | - |
dc.contributor.googleauthor | Byoung Seok Ye | - |
dc.identifier.doi | 10.3988/jcn.2022.0358 | - |
dc.contributor.localId | A06311 | - |
dc.contributor.localId | A06357 | - |
dc.contributor.localId | A06359 | - |
dc.contributor.localId | A06069 | - |
dc.contributor.localId | A06105 | - |
dc.contributor.localId | A05133 | - |
dc.contributor.localId | A01982 | - |
dc.contributor.localId | A04603 | - |
dc.relation.journalcode | J01327 | - |
dc.identifier.eissn | 2005-5013 | - |
dc.identifier.pmid | 37455503 | - |
dc.subject.keyword | Alzheimer disease | - |
dc.subject.keyword | dementia with Lewy bodies | - |
dc.subject.keyword | neuropsychological assessment | - |
dc.contributor.alternativeName | Kang, Sung Woo | - |
dc.contributor.affiliatedAuthor | 강성우 | - |
dc.contributor.affiliatedAuthor | 윤소훈 | - |
dc.contributor.affiliatedAuthor | 나한규 | - |
dc.contributor.affiliatedAuthor | 이영건 | - |
dc.contributor.affiliatedAuthor | 전세운 | - |
dc.contributor.affiliatedAuthor | 백경원 | - |
dc.contributor.affiliatedAuthor | 손영호 | - |
dc.contributor.affiliatedAuthor | 예병석 | - |
dc.citation.volume | 19 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 521 | - |
dc.citation.endPage | 529 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL NEUROLOGY, Vol.19(6) : 521-529, 2023-11 | - |
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