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Carbon Ion Radiotherapy in the Treatment of Hepatocellular Carcinoma

Authors
 Hwa Kyung Byun  ;  Changhwan Kim  ;  Jinsil Seong 
Citation
 CLINICAL AND MOLECULAR HEPATOLOGY, Vol.29(4) : 945-957, 2023-10 
Journal Title
CLINICAL AND MOLECULAR HEPATOLOGY
ISSN
 2287-2728 
Issue Date
2023-10
MeSH
Carbon / therapeutic use ; Carcinoma ; Hepatocellular* / pathology ; Heavy Ion Radiotherapy* / adverse effects ; Humans ; Ions / therapeutic use ; Liver Neoplasms* / pathology
Keywords
Carbon ion radiotherapy ; Hepatocellular carcinoma ; Particle therapy ; Radiotherapy
Abstract
Hepatocellular carcinoma (HCC) is a highly lethal cancer with limited treatment options and poor prognosis. Carbon ion radiotherapy (CIRT) has emerged as a promising treatment modality for HCC due to its unique physical and biological properties. CIRT uses carbon ions to target and destroy cancer cells with a high precision and efficacy. The Bragg Peak phenomenon allows precise dose delivery to the tumor while minimizing damage to healthy tissues. In addition, the high relative biological effectiveness of carbon ions can be shown against radioresistant and hypoxic tumor areas. CIRT also offers a shorter treatment schedule than conventional radiotherapy, which increases patient convenience and compliance. The clinical outcomes of CIRT for HCC have shown excellent local control rates with minimal side effects. Considering its physical and biological properties, CIRT may be a viable option for complex clinical scenarios such as patients with poor liver function, large tumors, re-irradiation cases, and tumors close to critical organs. Further research and larger studies are needed to establish definitive indications for CIRT and to compare its efficacy with that of other treatment modalities. Nevertheless, CIRT offers a potential breakthrough in HCC management, providing hope for improved therapeutic outcomes and reduced treatment-related toxicities.
Files in This Item:
T202305893.pdf Download
DOI
10.3350/cmh.2023.0217
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Changhwan(김창환)
Byun, Hwa Kyung(변화경) ORCID logo https://orcid.org/0000-0002-8964-6275
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/196555
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