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Efficacy Analysis of Suprapapillary versus Transpapillary Self-Expandable Metal Stents According to the Level of Obstruction in Malignant Extrahepatic Biliary Obstruction

Authors
 Sung Yong Han  ;  Tae Hoon Lee  ;  Sung Ill Jang  ;  Dong Uk Kim  ;  Jae Kook Yang  ;  Jae Hee Cho  ;  Min Je Sung  ;  Chang-Il Kwon  ;  Jin-Seok Park  ;  Seok Jeong  ;  Don Haeng Lee  ;  Sang-Heum Park  ;  Dong Ki Lee 
Citation
 GUT AND LIVER, Vol.17(5) : 806-813, 2023-09 
Journal Title
GUT AND LIVER
ISSN
 1976-2283 
Issue Date
2023-09
MeSH
Ampulla of Vater* / surgery ; Cholestasis* / etiology ; Cholestasis* / surgery ; Humans ; Neoplasms* / etiology ; Retrospective Studies ; Self Expandable Metallic Stents* / adverse effects ; Stents / adverse effects
Keywords
Adverse events ; Ampulla of Vater ; Bile duct neoplasms ; Endoscopic retrograde cholangiopancreatography ; Self expandable metallic stents
Abstract
Background/aims: The use of a self-expandable metal stent (SEMS) is recommended for unresectable malignant biliary obstruction (MBO). Stent-related adverse events might differ according to the position of the stent through the ampulla of Vater (AOV). We retrospectively evaluated SEMS patency and adverse events according to the position of the SEMS.

Methods: In total, 280 patients who underwent endoscopic SEMS placement due to malignant distal biliary obstruction were analyzed retrospectively. Suprapapillary and transpapillary SEMS insertions were performed on 51 patients and 229 patients, respectively.

Results: Between the suprapapillary group (SPG) and transpapillary group (TPG), the stent patency period was not significantly different (median [95% confidence interval]: 107 days [82.3 to 131.7] vs 120 days [99.3 to 140.7], p=0.559). There was also no significant difference in the rate of adverse events. In subgroup analysis, the stent patency for an MBO located within 2 cm from the AOV was found to be significantly shorter than that for an MBO located more than 2 cm from the AOV in the SPG (64 days [0 to 160.4] vs 127 days [82.0 to 171.9], p<0.001) and TPG (87 days [52.5 to 121.5] vs 130 [97.0 to 162.9], p<0.001). Patients with an MBO located within 2 cm from the AOV in both groups had a higher percentage of duodenal invasion (SPG: 40.0% vs 4.9%, p=0.002; TPG: 28.6% vs 2.9%, p<0.001) than patients with an MBO located more than 2 cm from the AOV.

Conclusions: The SPG and TPG showed similar results in terms of stent patency and rate of adverse events. However, patients with an MBO located within 2 cm from the AOV had a higher percentage of duodenal invasion with shorter stent patency than those with an MBO located more than 2 cm from the AOV, regardless of stent position.
Files in This Item:
T202305888.pdf Download
DOI
10.5009/gnl220437
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Dong Ki(이동기) ORCID logo https://orcid.org/0000-0002-0048-9112
Jang, Sung Ill(장성일) ORCID logo https://orcid.org/0000-0003-4937-6167
Cho, Jae Hee(조재희) ORCID logo https://orcid.org/0000-0003-4174-0091
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/196553
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